Results | viHumans

UniProt ID

P09312

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

ORF65[Gene ID: 1487702 ]

Protein Name

Envelope protein US9 (Envelope protein 65) (ORF65 protein)

Organism Name

Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Varicellovirus> Human Herpesvirus 3 (HHV-3) (Varicella-zoster Virus)> Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

RefSeq

NC_001348.1 ; X04370.1

PubMed ID

6321154 ; 3018124 ; 11162819 ; 19420087

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1487702

Reactome

Not Available

Sequence

							MAGQNTMEGEAVALLMEAVVTPRAQPNNTTITAIQPSRSAEKCYYSDSENETADEFLRRIGKYQHKIYHRKKFCYITLIIVFVFAMTGAAFALGYITSQF
VG
						

Length

102

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Essential for the anterograde spread of the infection throughout the host nervous system. Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019031 ; GO:0020002 ; GO:0044178 ; GO:0055036 ;
GO:0075733

Subcellular Location

♦ Virion membrane
♦ Single-pass type II membrane protein . Host Golgi apparatus membrane
♦ Single-pass type II membrane protein . Host Golgi apparatus, host trans-Golgi network . Host cell membrane
♦ Single-pass type II membrane protein . Note=During virion morphogenesis, this protein accumulates in the trans-Golgi where secondary envelopment occurs. .

Domain(s)

Not Available

Motif(s)

MOTIF 14 15 Di-leucine internalization motif.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available