Results | viHumans

UniProt ID

P09294

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

TRM3 45/42

Protein Name

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit) [Cleaved into: Gene 42 protein]

Organism Name

Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Varicellovirus> Human Herpesvirus 3 (HHV-3) (Varicella-zoster Virus)> Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

RefSeq

NC_001348.1 ; X04370.1

PubMed ID

3018124

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSLIMFGRTLGEESVRYFERLKRRRDERFGTLESPTPCSTRQGSLGNATQIPFLNFAIDVTRRHQAVIPGIGTLHNCCEYIPLFSATARRAMFGAFLSST
GYNCTPNVVLKPWRYSVNANVSPELKKAVSSVQFYEYSPEEAAPHRNAYSGVMNTFRAFSLSDSFCQLSTFTQRFSYLVETSFESIEECGSHGKRAKVDV
PIYGRYKGTLELFQKMILMHTTHFISSVLLGDHADRVDCFLRTVFNTPSVSDSVLEHFKQKSTVFLVPRRHGKTWFLVPLIALVMATFRGIKVGYTAHIR
KATEPVFEGIKSRLEQWFGANYVDHVKGESITFSFTDGSYSTAVFASSHNTNGIRGQDFNLLFVDEANFIRPDAVQTIVGFLNQTNCKIIFVSSTNTGKA
STSFLYNLRGSSDQLLNVVTYVCDDHMPRVLAHSDVTACSCYVLNKPVFITMDGAMRRTADLFMADSFVQEIVGGRKQNSGGVGFDRPLFTKTARERFIL
YRPSTVANCAILSSVLYVYVDPAFTSNTRASGTGVAIVGRYKSDWIIFGLEHFFLRALTGTSSSEIGRCVTQCLGHILALHPNTFTNVHVSIEGNSSQDS
AVAISLAIAQQFAVLEKGNVLSSAPVLLFYHSIPPGCSVAYPFFLLQKQKTPAVDYFVKRFNSGNIIASQELVSLTVKLGVDPVEYLCKQLDNLTEVIKG
GMGNLDTKTYTGKGTTGTMSDDLMVALIMSVYIGSSCIPDSVFMPIK
						

Length

747

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.

EC

3.1.-.-

Experimentally known GO terms

GO:0003677 ; GO:0006323 ; GO:0016787 ; GO:0042025

Subcellular Location

Host nucleus . Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2. .

Domain(s)

Not Available

Motif(s)

MOTIF 194 198 Nuclear localization signal. ; MOTIF 267 274 Walker A motif. ; MOTIF 361 366 Walker B motif.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

♦ACT_SITE 366 366 For ATPase activity.
♦ ACT_SITE 521 521 For nuclease activity.
♦ ACT_SITE 593 593 For nuclease activity.
♦ ACT_SITE 722 722 For nuclease activity.

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available