Results | viHumans

UniProt ID

P09269

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

ORF4

Protein Name

mRNA export factor ICP27 homolog (Immediate-early protein 4) (IE4) (Transcriptional transactivator IE4)

Organism Name

Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Varicellovirus> Human Herpesvirus 3 (HHV-3) (Varicella-zoster Virus)> Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

RefSeq

NC_001348.1 ; X04370.1

PubMed ID

3018124 ; 9261438 ; 10873781 ; 10889190 ; 19924249

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MASASIPTDPDVSTICEDFMNLLPDEPSDDFALEVTDWANDEAIGSTPGEDSTTSRTVYVERTADTAYNPRYSKRRHGRRESYHHNRPKTLVVVLPDSNH
HGGRDVETGYARIERGHRRSSRSYNTQSSRKHRDRSLSNRRRRPTTPPAMTTGERNDQTHDESYRLRFSKRDARRERIRKEYDIPVDRITGRAIEVVSTA
GASVTIDSVRHLDETIEKLVVRYATIQEGDSWASGGCFPGIKQNTSWPELMLYGHELYRTFESYKMDSRIARALRERVIRGESLIEALESADELLTWIKM
LAAKNLPIYTNNPIVATSKSLLENLKLKLGPFVRCLLLNRDNDLGSRTLPELLRQQRFSDITCITTYMFVMIARIANIVVRGSKFVEYDDISCNVQVLQE
YTPGSCLAGVLEALITHQRECGRVECTLSTWAGHLSDARPYGKYFKCSTFNC
						

Length

452

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Multifunctional regulator of the expression of viral genes that mediates nuclear export of viral intronless mRNAs. This immediate early (EI) protein promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0006351 ; GO:0006355 ; GO:0016032 ; GO:0030430 ;
GO:0042025 ; GO:0046872

Subcellular Location

Host cytoplasm . Host nucleus . Note=Shuttles between the nucleus and the cytoplasm (Probable). IE4 utilizes, at least, XPO1/CRM1 as a cofactor for nuclear export. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available