Results | viHumans

UniProt ID

P08490

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Not Available

Protein Name

♦Genome polyprotein [Cleaved into: Protein 3B (P3B) (VPg)
♦ Picornain 3C (EC 3.4.22.28) (Protease 3C) (P3C)] (Fragment)

Organism Name

Echo 9 Virus (EV-9) (Coxsackievirus A23)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Positive-strand Viruses> No DNA Stage> Picornavirales> Picornaviridae> Enterovirus> Enterovirus B> Echo 9 Virus (EV-9) (Coxsackievirus A23)

RefSeq

Not Available

PubMed ID

3512851

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							GAYTGMPNKKPKVPTLRQAKVQGPAFEFAVAMMKRNASTVKTEYGEFTMLGIYDRWAVLPRHAKPGPSILMNDQEVGVLDAKELVDKDGINLELTLLKLN
RNEKFRDIRGFLAREEVEVNEAVLAINTSKFPNMYIPVGQVTDYGFLNLGGTPTKRMLMYNFPTRAGQCGGVLMSTGKVLGIHVGGNGHHGFSAALLRHY
FNEEQ
						

Length

205

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-08-1988

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease (By similarity).

EC

3.4.22.28

Experimentally known GO terms

GO:0003723 ; GO:0004197 ; GO:0018144 ; GO:0019012 ; GO:0019062 ;
GO:0030430 ; GO:0046718

Subcellular Location

♦ Protein 3B: Virion .
♦ Picornain 3C: Host cytoplasm .

Domain(s)

DOMAIN 23 188 Peptidase C3.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

♦ACT_SITE 62 62 For picornain 3C activity.
♦ ACT_SITE 93 93 For picornain 3C activity.
♦ ACT_SITE 169 169 For picornain 3C activity.

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available