Results | viHumans

UniProt ID

P08325

Status

Reviewed

Host

Aedes [TaxID: 7158]; Bos Taurus (Bovine) [TaxID: 9913]; Culicoides [TaxID: 58271]; Equus Asinus (Donkey) (Equus Africanus Asinus) [TaxID: 9793]; Equus Caballus (Horse) [TaxID: 9796]; Homo Sapiens (Human) [TaxID: 9606]; Lutzomyia [TaxID: 252607]; Musca Domestica (House Fly) [TaxID: 7370]; Simuliidae (black Flies) [TaxID: 7190]; Sus Scrofa (Pig) [TaxID: 9823]

Gene Name

M

Protein Name

Matrix protein

Organism Name

Vesicular Stomatitis New Jersey Virus (strain Ogden Subtype Concan) (VSNJV)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Rhabdoviridae> Vesiculovirus> New Jersey Vesiculovirus> Vesicular Stomatitis New Jersey Virus> Vesicular Stomatitis New Jersey Virus (strain Ogden Subtype Concan) (VSNJV)

RefSeq

NC_024473.1 ; JX121109.2

PubMed ID

3006343 ; 16962155

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSSFKKILGLSSKSHKKSKKMGLPPPYDESCPMETQPSAPLSNDFFGMEDMDLYDKDSLRYEKFRFMLKMTVRSNKPFRSYDDVTAAVSQWDNSYIGMVG
KRPFYKIIAVIGSSHLQATPAVLADLNQPEYYATLTGRCFLPHRLGLIPPMFNVQETFRKPFNIGLYKGTLDFTFTVSDDESNEKVPHVWDYMNPKYQSQ
IQQEGLKFGLILSKKATGTWVLDQLSPFK
						

Length

229

Alternate Sequence

VAR_SEQ 1 50 Missing (in isoform M3) ; VAR_SEQ 1 32 Missing (in isoform M2)

Non-standard residue

Not Available

Date of last Sequence modification

01-08-1988

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a major role in assembly and budding of virion. Condensates the ribonucleocapsid core during virus assembly. Shut off cellular transcription by inhibiting mRNA nuclear export through direct interaction with host RAE1-NUP98 complex. This shutoff presumably inhibits interferon signaling and thus establishment of antiviral state in virus infected cells. Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0019031 ; GO:0039522 ; GO:0039657 ; GO:0039660 ; GO:0039702 ;
GO:0044200 ; GO:0055036

Subcellular Location

♦ Virion membrane
♦ Peripheral membrane protein. Host endomembrane system
♦ Peripheral membrane protein. Host nucleus membrane
♦ Peripheral membrane protein .

Domain(s)

Not Available

Motif(s)

MOTIF 24 27 PPXY motif.; MOTIF 37 40 PTAP/PSAP motif.

Methods of 3D structure generation

X-ray crystallography (1)

Experimetally known structure

2W2R

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available