Results | viHumans

UniProt ID

P08313

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

UL47

Protein Name

Tegument protein UL47 (82/81 kDa tegument protein) (VMW82/81) (VP13/14)

Organism Name

Human Herpesvirus 1 (strain F) (HHV-1) (Human Herpes Simplex Virus 1)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Simplexvirus> Human Herpesvirus 1 (HHV-1) (Human Herpes Simplex Virus 1)> Human Herpesvirus 1 (strain F) (HHV-1) (Human Herpes Simplex Virus 1)

RefSeq

Not Available

PubMed ID

3029433 ; 15795259 ; 18596102

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSAREPAGRRRRASTRPRASPVADEPAGDGVGFMGYLRAVFRGDDDSELEALEEMAGDEPPVRRRREGPRARRRRASEAPPTSHRRASRQRPGPDAARSQ
SVRGRLDDDDEVPRGPPQARQGGYLGPVDARAILGRVGGSRVAPSPLFLEELQYEEDDYPEDVGPEDGGGARSPPKVEVLEGRVPGPELRAAFPLDRLAP
QVAVWDESVRSALALGHPAGFYPCPDSAFGLSRVGVMHFASPDNPAVFFRQTLQQGEALAWYITGDGILDLTDRRTKTSPAQAMSFLADAVVRLAINGWV
CGTRLHAEARGSDLDDRAAELRRQFASLTALRPVGAAAVPLLSAGGLVSPQSGPDAAVFRSSLGSLLYWPGVRALLDRDCRVAARYAGRMTYLATGALLA
RFNPDAVRCVLTREAAFLGRVLDVLAVMAEQTVHWLSVVVGARLHPHVHHPAFADVAREELFRALPLGSPAVVGAEHEALGDTAARRLLANSGLNAVLGA
AVYALHTALATVTLKYARACGDAHRRRDDAAATRRILAAGLVLQRLLGFADTVVACVTLAAFDGGFTAPEVGTYTPLRYACVLRATQPLYARTTPAKFWA
DVRAAAEHVDLRPASSAPRAPVSGTADPAFLLKDLEPFPPAPVSGGSVLGPGVRVVDIMSQFRKLLMGDEGAAALRAHVSGRRATGLGGPPRP
						

Length

693

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

22-09-2009

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Plays also a role in the primary envelopement of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0006351 ; GO:0006355 ; GO:0019033 ; GO:0030430 ;
GO:0042025

Subcellular Location

Virion tegument . Host nucleus . Host cytoplasm . Note=Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus. .

Domain(s)

Not Available

Motif(s)

MOTIF 63 75 Nuclear localization signal. ; MOTIF 647 670 Nuclear export signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available