Results | viHumans

UniProt ID

P07885

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

L3

Protein Name

Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

Organism Name

Human Adenovirus E Serotype 4 (HAdV-4) (Human Adenovirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus E> Human Adenovirus E Serotype 4 (HAdV-4) (Human Adenovirus 4)

RefSeq

NC_003266.2 ; AY487947.1

PubMed ID

3301540

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MAAGSGEQELRAIIRDLGCGPYFLGTFDKRFPGFMAPHKVACAIVNTAGRETGGEHWLAFAWNPRSNTCYLFDPFGFSDQRLKQIYQFEYEGLLRRSALA
TKDRCVTWKSHQTCRVRVGRCGFSAACSTACAWPTPMDKNPTMNLLTGVPNGMLQSPQVEPTLRRNQEALYRFLNSHSAYFRSHRARIEKATAFDRMNQD
M
						

Length

201

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-08-1988

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cell cytoskeletal keratins K7 and K18.

EC

3.4.22.39

Experimentally known GO terms

GO:0003677 ; GO:0004197 ; GO:0019012 ; GO:0042025

Subcellular Location

Virion . Host nucleus . Note=Present in about 10 copies per virion. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

♦ACT_SITE 56 56
♦ ACT_SITE 73 73
♦ ACT_SITE 121 121

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available