Results | viHumans

UniProt ID

P06944

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]; Sus Scrofa (Pig) [TaxID: 9823]

Gene Name

NS

Protein Name

Non-structural protein 1 (NS1) (NS1A)

Organism Name

Influenza C Virus (strain C/California/1978)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Orthomyxoviridae> Gammainfluenzavirus> Influenza C Virus> Influenza C Virus (strain C/California/1978)

RefSeq

NC_006307.2 ; AB126193.2 ; NC_006308.2 ; AB126196.2 ; NC_006309.2 ; AB126191.2 ; NC_006310.2 ;
AB283001.1 ; NC_006311.1 ; AB126195.1 ; NC_006312.2 ; AB126191.2 ; NC_006306.2 ; AB283001.1

PubMed ID

4032535 ; 15310173

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDGELLFNGTILQAESTTMTPASVEMKGKKFPIDFVPSNI
APIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGYLIAKQVAGIETGIRKCFRCIKSGFV
MATDEISLIILQSIKSGAQLDPYWGNETPDIDKTEAYMLSLREAGP
						

Length

246

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

21-02-2006

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Prevents the establishment of the cellular antiviral state initiated by host DDX58, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Participates also in the upregulation of the splicing of viral mRNAs.

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0030430 ; GO:0039502 ; GO:0039540 ; GO:0042025

Subcellular Location

Host cytoplasm . Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available