Results | viHumans

UniProt ID

P04874

Status

Reviewed

Host

Cervidae (deer) [TaxID: 9850]; Homo Sapiens (Human) [TaxID: 9606]; Ochlerotatus Triseriatus (Eastern Treehole Mosquito) (Aedes Triseriatus) [TaxID: 7162]; Tamias [TaxID: 13712]

Gene Name

N

Protein Name

Non-structural protein NS-S

Organism Name

Bunyavirus La Crosse

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Bunyavirales> Peribunyaviridae> Orthobunyavirus> California Encephalitis Orthobunyavirus> Bunyavirus La Crosse

RefSeq

NC_004108.1 ; AF528165.1 ; NC_004109.1 ; AF528165.1 ; NC_004110.1 ; AF528167.1

PubMed ID

6834480 ; 6684362

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MMSHQQVQMDLILMQGIWTSVLKMQNHSTLLQLGSSSSMPQRPRLLSRVSQRGRLTLNLESGRWRLSIIIFLETGTTQLVTTILPSTDYLGI
						

Length

92

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

13-08-1987

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0001934 ; GO:0039657

Subcellular Location

Not Available

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available