Results | viHumans

UniProt ID

P04505

Status

Reviewed

Host

Aedes Aegypti (Yellowfever Mosquito) (Culex Aegypti) [TaxID: 7159]; Homo Sapiens (Human) [TaxID: 9606]

Gene Name

GP[Gene ID: 2648216 ]

Protein Name

♦Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2)
♦ Non-structural protein M (NSm)
♦ Glycoprotein C (Gc) (Glycoprotein G1)]

Organism Name

Bunyamwera Virus (BUNV)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Bunyavirales> Peribunyaviridae> Orthobunyavirus> Bunyamwera Orthobunyavirus> Bunyamwera Virus (BUNV)

RefSeq

NC_001925.1 ; D00353.1 ; NC_001926.1 ; D00353.1 ; NC_001927.1 ; M11852.1

PubMed ID

3753629 ; 7996137 ; 15367646 ; 16873265 ; 17609275

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:2648216

Reactome

Not Available

Sequence

							MRILILLLAVTQLAVSSPVITRCFHGGQLIAERKSQTSISEFCIKDDVSMLKSEIVYTKNDTGIFGHSKVFRHWTITDWKACNPVVTAGGSINVIEVDKN
LNLVTRNYVCTGDCTITVDRKNAQIIFQTDKLNHFEVTGTTISTGWFKSKASVTLDRTCEHIKVSCGKKTLQFHACFKQHMSCVRFLHRSILPGSMAISI
CQNIELIIITILALCIFIIMIILTKTYICYVLIPVFMPIAFAYGWAYNRSCKKCTCCGLAYHPFTNCGSYCVCGSKFETSDRMRMHRESGLCQGFKSLRV
ARRLCKSKGSSLIISILLSVLILSFVTPIEGTLTNYPTDQKYTLDEIADVLQAKTHEDSTKYYIILYTSLFGAGLTIIFAGVALGLTIILEVLTKINVIF
CNECNMYHSKKSIKYVGDFTNKCGFCTCGLLEDPEGVVVHKAKKSCTYSYQINWVRGIMIFVAFLFVIQNTIIMVAAEEDCWKNEELKEDCVGPLIAPKD
CTDKDHKTYLSEASLLATAKKITQVDAENVEILGKTMESAIRVIERQKTYHRMHLLEAVFLNKHCDYYKMFEHNSGYSQVKWRMMIKTQHFDICALQANS
PFCAQCIADNSCAQGSWEFDTHMNSTYSSKVDNFKHDFSLFLRIFEAAFPGTAYVHLLTNIKEKKPYQAVSMIEKIKKKFPNNKLLIGYLDFGKYLLGLS
HASTYELQQRQLDKLYQPTELTRSGGQQTSLANSVVGQATKECKKYKDVSCLSPRFGIPLEDLISCCDQPNYNIYKKPKKVYKAHDKEETWCINDQHCLV
DFVPAEADTVEKLKPMKCWLVDPGKNDDVYSIAIKTCRVVDKGVCTVNSQKWNIIKCDSGPLYYSDHIPGEDTGNDIGHYCVSAGCKTDRYPINPDVVTD
CVWEFTSRKSQYIGKISMQSLEDYEKALTDRLTHTLETYSFAPLENLPHIKPVYKYITAQGVENSDGIEGAFITASIPAAGGTSIGYNVRSKDGFPLLDL
IVFVKSAVIKSTYNHIYDTGPTISINTKHDEHCTGQCPSNIEHEANWLTFSQERTSRWGCEEFGCLAVNTGCVFGSCQDVIRPETKVYRKAVDEVVILTV
CITYPGHTFCTEINAIEPKITEEIELQFKTVDTKTLPYIVAVNNHKLYSGQINDLGTFGQMCGNVQKTNSSILGTGTPKFDYTCHGASRKDIIVRRCYNN
NFDSCKLLKEETQLIFNDDHDTITVYNTNHLIGELAIKLILGDIQYKLFTETLDLQIDAKCVGCPDCFESYSCNFQIVSNIDTICSLEGPCDTFHNRISI
KAMQQNYAVKLSCQKDPRPSGTFKICNREYTVVFHTVAKDDKIEINVGDQTSFIKEKDDRCKTWLCRVRDEGISVIFEPIKAFFGSYFSIFFYIIVVVVV
GFLIIYIFMPMFMKLKEVLKANEKLYLQEIKQK
						

Length

1433

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

13-08-1987

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

♦Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).
♦ Non-structural protein M: Plays a role virion budding at Golgi tubes and in subcellular location of Glycoprotein C protein.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019048 ; GO:0019062 ; GO:0039654 ; GO:0039702 ;
GO:0044167 ; GO:0044178 ; GO:0046760 ; GO:0055036

Subcellular Location

♦ Glycoprotein C: Virion membrane
♦ Single-pass type I membrane protein . Host Golgi apparatus membrane
♦ Single-pass type I membrane protein . Host endoplasmic reticulum membrane
♦ Single-pass type I membrane protein . Note=Glycoprotein C alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of Glycoprotein N and Glycoprotein C results in efficient transport of Glycoprotein C to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs.
♦ Glycoprotein N: Virion membrane
♦ Single-pass type I membrane protein . Host Golgi apparatus membrane
♦ Single-pass type I membrane protein . Note=Glycoprotein N is retained in the Golgi complex through a Golgi retention signal, which resides in the Glycoprotein N transmembrane region.
♦ Non-structural protein M: Host Golgi apparatus membrane
♦ Multi-pass membrane protein .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available