Results | viHumans

UniProt ID

P04295

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

TRM3 UL15[Gene ID: 2703385 ]

Protein Name

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

Organism Name

Human Herpesvirus 1 (strain 17) (HHV-1) (Human Herpes Simplex Virus 1)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Simplexvirus> Human Herpesvirus 1 (HHV-1) (Human Herpes Simplex Virus 1)> Human Herpesvirus 1 (strain 17) (HHV-1) (Human Herpes Simplex Virus 1)

RefSeq

Not Available

PubMed ID

2839594 ; 3010237 ; 12743292 ; 16920825 ; 17392365 ; 18687036 ; 19224991 ; 23596306

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:2703385

Reactome

Not Available

Sequence

							MFGQQLASDVQQYLERLEKQRQLKVGADEASAGLTMGGDALRVPFLDFATATPKRHQTVVPGVGTLHDCCEHSPLFSAVARRLLFNSLVPAQLKGRDFGG
DHTAKLEFLAPELVRAVARLRFKECAPADVVPQRNAYYSVLNTFQALHRSEAFRQLVHFVRDFAQLLKTSFRASSLTETTGPPKKRAKVDVATHGRTYGT
LELFQKMILMHATYFLAAVLLGDHAEQVNTFLRLVFEIPLFSDAAVRHFRQRATVFLVPRRHGKTWFLVPLIALSLASFRGIKIGYTAHIRKATEPVFEE
IDACLRGWFGSARVDHVKGETISFSFPDGSRSTIVFASSHNTNGIRGQDFNLLFVDEANFIRPDAVQTIMGFLNQANCKIIFVSSTNTGKASTSFLYNLR
GAADELLNVVTYICDDHMPRVVTHTNATACSCYILNKPVFITMDGAVRRTADLFLADSFMQEIIGGQARETGDDRPVLTKSAGERFLLYRPSTTTNSGLM
APDLYVYVDPAFTANTRASGTGVAVVGRYRDDYIIFALEHFFLRALTGSAPADIARCVVHSLTQVLALHPGAFRGVRVAVEGNSSQDSAVAIATHVHTEM
HRLLASEGADAGSGPELLFYHCEPPGSAVLYPFFLLNKQKTPAFEHFIKKFNSGGVMASQEIVSATVRLQTDPVEYLLEQLNNLTETVSPNTDVRTYSGK
RNGASDDLMVAVIMAIYLAAQAGPPHTFAPITRVS
						

Length

735

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.

EC

3.1.-.-

Experimentally known GO terms

GO:0003677 ; GO:0006323 ; GO:0016787 ; GO:0042025

Subcellular Location

Host nucleus , , . Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2. , .

Domain(s)

Not Available

Motif(s)

MOTIF 183 189 Nuclear localization signal. ; MOTIF 258 265 Walker A motif. ; MOTIF 352 357 Walker B motif.

Methods of 3D structure generation

X-ray crystallography (2)

Experimetally known structure

4IOX 5HUW

Active Site(s)

♦ACT_SITE 357 357 For ATPase activity.
♦ ACT_SITE 509 509 For nuclease activity.
♦ ACT_SITE 581 581 For nuclease activity.
♦ ACT_SITE 707 707 For nuclease activity.

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available