Results | viHumans

UniProt ID

P04291

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

UL14[Gene ID: 2703384 ]

Protein Name

Tegument protein UL14

Organism Name

Human Herpesvirus 1 (strain 17) (HHV-1) (Human Herpes Simplex Virus 1)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Simplexvirus> Human Herpesvirus 1 (HHV-1) (Human Herpes Simplex Virus 1)> Human Herpesvirus 1 (strain 17) (HHV-1) (Human Herpes Simplex Virus 1)

RefSeq

Not Available

PubMed ID

2839594 ; 9499055 ; 3010237 ; 17218138 ; 10590088 ; 18032514 ; 27440890

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:2703384

Reactome

Not Available

Sequence

							MDRDAAHAALRRRLAETHLRAEIYKDQTLQLHREGVSTQDPRFVGAFMAAKAAHLELEARLKSRARLEMMRQRATCVKIRVEEQAARRDFLTAHRRYLDP
ALGERLDAVDDRLADQEEQLEEAATNASLWGDGDLAEGWMSPADSDLLVMWQLTSAPKVHANGPSRIGSHPTYTPTPTGPPGAPAAPLSRTPPSPAPPTG
PATDPASASGFARDYPDGE
						

Length

219

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

15-08-2003

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Contributes to the nuclear transport of the viral transcriptional activator VP16 during the early phase of infection. Therefore, participates indirectly in the regulation of the immediate-early gene expression. Additionally, seems to be important for efficient nuclear targeting of capsids. The UL51-UL14 complex regulates final viral envelopment for efficient viral replication (PubMed:27440890).

EC

Not Available

Experimentally known GO terms

GO:0019033 ; GO:0030430 ; GO:0042025

Subcellular Location

Virion tegument . Host cytoplasm . Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available