Reviewed
Cavia Cutleri (Guinea Pig) [TaxID: 10144]; Homo Sapiens (Human) [TaxID: 9606]; Nephelomys Albigularis (Tomes's Rice Rat) (Oryzomys Albigularis) [TaxID: 530178]
N[Gene ID: 5075742 ]
Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Pichinde Mammarenavirus (PICV) (Pichind Mammarenavirus)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Arenaviridae> Mammarenavirus> Pichinde Mammarenavirus (PICV) (Pichind Mammarenavirus)
Not Available
Various pathway(s) in which protein is involved
Not Available
MSDNIPSFRWVQSLRRGLSNWTHPVKADVLSDTRALLSALDFHKVAQVQRMVRKDKRTDSDLTKLRDMNKEVDALMNMRSVQRDNVLKVGGLAKEELMEL
ASDLDKLRKKVTRTEGLSQPGVYEGNLTNTQLEQRAEILRSMGFANARPAGNRDGVVKVWDIKDNTLLINQFGSMPALTIACMTEQGGEQLNDVVQALSA
LGLLYTVKFPNMTDLEKLTQQHSALKIISHEPSALNISGYNLSLSAAVKAAACMIDGGNMLETIQVKPSMFSTLIKSLLQIKNREGMFVSTTPGQRNPYE
NLLYKICLSGDGWPYIGSRSQVQGRAWDNTTVDLDSKPSAIQPPVRNGGSPDLKQIPKEKEDTVVSSIQMLDPRATTWIDIEGTPNDPVEMAIYQPDTGN
YIHCYRFPHDEKSFKEQSKYSHGLLLKDLADAQPGLISSIIRHLPQNMVFTAQGSDDIIRLFEMHGRRDLKVLDVKLSAEQARTFEDEIWERYNQLCTKH
KGLVIKKKKKGAVQTTANPHCALLDTIMFDATVTGWVRDQKPMRCLPIDTLYRNNTDLINL
ASDLDKLRKKVTRTEGLSQPGVYEGNLTNTQLEQRAEILRSMGFANARPAGNRDGVVKVWDIKDNTLLINQFGSMPALTIACMTEQGGEQLNDVVQALSA
LGLLYTVKFPNMTDLEKLTQQHSALKIISHEPSALNISGYNLSLSAAVKAAACMIDGGNMLETIQVKPSMFSTLIKSLLQIKNREGMFVSTTPGQRNPYE
NLLYKICLSGDGWPYIGSRSQVQGRAWDNTTVDLDSKPSAIQPPVRNGGSPDLKQIPKEKEDTVVSSIQMLDPRATTWIDIEGTPNDPVEMAIYQPDTGN
YIHCYRFPHDEKSFKEQSKYSHGLLLKDLADAQPGLISSIIRHLPQNMVFTAQGSDDIIRLFEMHGRRDLKVLDVKLSAEQARTFEDEIWERYNQLCTKH
KGLVIKKKKKGAVQTTANPHCALLDTIMFDATVTGWVRDQKPMRCLPIDTLYRNNTDLINL
561
Not Available
Not Available
21-07-1986
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and therby participates in the suppression of interferon induction.
3.1.13.-
GO:0003723 ; GO:0016787 ; GO:0019013 ; GO:0019029 ; GO:0030430 ;
GO:0039689 ; GO:0039696 ; GO:0039724 ; GO:0046872
GO:0039689 ; GO:0039696 ; GO:0039724 ; GO:0046872
Virion . Host cytoplasm .
Not Available
Not Available
X-ray crystallography (1)
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available