Results | viHumans

UniProt ID

P03282

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

IX[Gene ID: 2653012 ]

Protein Name

Hexon-interlacing protein (Protein IX)

Organism Name

Human Adenovirus C Serotype 2 (HAdV-2) (Human Adenovirus 2)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus C> Human Adenovirus C Serotype 2 (HAdV-2) (Human Adenovirus 2)

RefSeq

AC_000007.1 ;

PubMed ID

6985473 ; 7142161 ; 22939182 ; 21925109 ; 22754652

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:2653012

Reactome

Not Available

Sequence

							MSANSFDGSIVSSYLTTRMPPWAGVRQNVMGSSIDGRPVLPANSTTLTYETVSGTPLETAASAAASAAAATARGIVTDFAFLSPLASSAASRSSARDDKL
TALLAQLDSLTRELNVVSQQLLDLRQQVSALKASSPPNAV
						

Length

140

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1995

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Structural component of the virion that forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons (By similarity). Dispensable for assembly. During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force (PubMed:21925109). The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus (PubMed:21925109).

EC

Not Available

Experimentally known GO terms

GO:0019061 ; GO:0031423 ; GO:0042025 ; GO:0046718 ; GO:0098021

Subcellular Location

Virion . Host nucleus . Note=Located in the canyons between the hexons on the outer surface of the capsid. Forms a sort of hairnet on the outer side of the virion. Present in 240 copies per virion. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available