Results | viHumans

UniProt ID

P03228

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

BARF1[Gene ID: 3783772 ]

Protein Name

Secreted protein BARF1 (33 kDa early protein) (p33)

Organism Name

Epstein-Barr Virus (strain B95-8) (HHV-4) (Human Herpesvirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)> Epstein-Barr Virus (strain B95-8) (HHV-4) (Human Herpesvirus 4)

RefSeq

NC_007605.1 ; AJ507799.2

PubMed ID

6087149 ; 2555151 ; 9557689 ; 15064715 ; 15778977 ; 16054293 ; 16518412 ; 17872516 ; 18533018 ;
16647084

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3783772

Reactome

Not Available

Sequence

							MARFIAQLLLLASCVAAGQAVTAFLGERVTLTSYWRRVSLGPEIEVSWFKLGPGEEQVLIGRMHHDVIFIEWPFRGFFDIHRSANTFFLVVTAANISHDG
NYLCRMKLGETEVTKQEHLSVVKPLTLSVHSERSQFPDFSVLTVTCTVNAFPHPHVQWLMPEGVEPAPTAANGGVMKEKDGSLSVAVDLSLPKPWHLPVT
CVGKNDKEEAHGVYVSGYLSQ
						

Length

221

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

21-07-1986

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.

EC

Not Available

Experimentally known GO terms

GO:0005576 ; GO:0042802

Subcellular Location

Secreted . Note=Massively secreted in the serum of EBV-induced nasophyryngeal carcinoma patients.

Domain(s)

♦DOMAIN 21 120 Ig-like 1.
♦ DOMAIN 124 220 Ig-like 2.

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (4)

Experimetally known structure

2CH8 3UEZ 4ADF 4ADQ

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available