Results | viHumans

UniProt ID

P03208

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

BILF1[Gene ID: 3783707 ]

Protein Name

G-protein coupled receptor BILF1

Organism Name

Epstein-Barr Virus (strain B95-8) (HHV-4) (Human Herpesvirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)> Epstein-Barr Virus (strain B95-8) (HHV-4) (Human Herpesvirus 4)

RefSeq

NC_007605.1 ; AJ507799.2

PubMed ID

6092825 ; 6087149 ; 15596846 ; 15596837 ; 19119421 ; 20622011 ; 21123379

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3783707

Reactome

Not Available

Sequence

							MLSTMAPGSTVGTLVANMTSVNATEDACTKSYSAFLSGMTSLLLVLLILLTLAGILFIIFVRKLVHRMDVWLIALLIELLLWVLGKMIQEFSSTGLCLLT
QNMMFLGLMCSVWTHLGMALEKTLALFSRTPKRTSHRNVCLYLMGVFCLVLLLIIILLITMGPDANLNRGPNMCREGPTKGMHTAVQGLKAGCYLLAAVL
IVLLTVIIIWKLLRTKFGRKPRLICNVTFTGLICAFSWFMLSLPLLFLGEAGSLGFDCTESLVARYYPGPAACLALLLIILYAWSFSHFMDSLKNQVTVT
ARYFRRVPSQST
						

Length

312

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

21-07-1986

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Constitutively active G protein-coupled receptor that plays a role in the modulation of host immunity. As a consequence of its constitutive activity, mediates host CXCR4 inhibition. Enhances degradation of host major histocompatibility complex class I antigens via lysosomes. Targets also newly synthesized MHC-I/peptide complexes en route to the host cell surface. Inhibits the host EIF2AK2/PKR phosphorylation.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0020002 ; GO:0039502 ; GO:0039504 ; GO:0039580 ;
GO:0046776

Subcellular Location

♦ Host cell membrane
♦ Multi-pass membrane protein .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available