Results | viHumans

UniProt ID

P03189

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

BOLF1[Gene ID: 3783723 ]

Protein Name

Inner tegument protein

Organism Name

Epstein-Barr Virus (strain B95-8) (HHV-4) (Human Herpesvirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)> Epstein-Barr Virus (strain B95-8) (HHV-4) (Human Herpesvirus 4)

RefSeq

NC_007605.1 ; AJ507799.2

PubMed ID

6087149 ; 15534216

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3783723

Reactome

Not Available

Sequence

							MASAMESDSSGGSGGADAQPPLAEVDGGLARVTRQLLLSGDDPAARLRALMPLELGIFGLGDLAQPVLVRDFLNTLTLMSGHAYPAAVLRHHAYYLLRAA
SFSRRSFGLGHLEAALDVLASSLPPTTASPATDDPLDGSRLIAETRALAAAYRRIIEEGSGEVLAVSGPTATFAFVEELVADTYLARWDAFPREGLSFYA
FNAAKTTLGRWLVTVYAETNRYPWAAAGQGQPTAADIKAMAVELVEHSGGGAGGGEGEESGGGLFHRPESLSSVVASLPLARRRAVEILGVYAEASGGQT
PPVAAVPVLAFDAARLRLLEPSGALFYDYVYEALLWDQTYGVPDSVIEAFLAGMAAEMEALAARVQEAAGSRASFSPAAIEQVATVLLSAGLNETVAGDY
AMMLASVPRVSRSRWRWLEATAALLESLSGFALHFFRLLPTASPTSRFARVARAAYLRAEAEAVDRRARRTSGPSTPAAAPAATAVGVGAAADPWDAVTP
LRIFIVPPPAAEYEQVAGDLSSELLRSLLWVRYSRLWQAPAPAPALPCKPPLLPGEQGRRQWTAAVAAAPRTDVEAYCRSLRAGQTARADPAYVHSPFFP
AAFIEFQIWPALRRVLSNELPKTRSLAALRWLVSFGSDLALPSPELTRARRPLELIYATVWEIYDGAPPMPGESPQAVGLRPLNLEGEGKAGDAGAEGAE
DEEGGGPWGLSSHDAVLRIMDAVREVSGIISETISASERAAEAPPLAWPTSLFSLLFTLRYSTTAESLGLATRRFLVSGETLSEDISRLTGAAWRLCSRP
LLYDAETGRVQIPLATEEEEEAVVAVKEKSVSSSPRHYSTDLQTLKSVVEGIQDVCRDAAARWALATADTATLRRRLLVPALRESRGIADHPLWAHTSEP
LRPDLEELNERVEHALELGYSLTGALRRSVAYRFRDYTFARLFQPPAIDAERAEAIVRRDARPPPVFIPAPRRLPQGGADTPPPLSMDDILYLGKSICKA
LVDVLDHHPAAPETTPIKTYTPAMDLNPEQITVTPRSPSVLAAFARTARVQTHHLVPALTDDSPSPVGQTPPPFRILPAKKLAAILLGNGRNASKRRASR
DLSPPPHGRWRAVLDSSPFSFSSSDFSDQDEGEGGEADLRGVPGGGGEGAYEEDRERPSDIDTAARAQKVETSCPRRRSPRTTPSPSRRASGGGGPDRGE
AEAHTYPPYLSAAAAASRVRPRTRRGATRRPPRPTAEDE
						

Length

1239

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

21-07-1986

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex.

EC

Not Available

Experimentally known GO terms

GO:0019033 ; GO:0019068 ; GO:0042025 ; GO:0044177

Subcellular Location

Virion tegument , . Host cytoplasm . Host nucleus . Host Golgi apparatus, host trans-Golgi network .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available