viHumans
P03176
Reviewed
Homo Sapiens (Human) [TaxID: 9606]
TK UL23[Gene ID: 24271467 ]
Thymidine kinase (EC 2.7.1.21)
Human Herpesvirus 1 (strain 17) (HHV-1) (Human Herpes Simplex Virus 1)
Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Simplexvirus> Human Herpesvirus 1 (HHV-1) (Human Herpes Simplex Virus 1)> Human Herpesvirus 1 (strain 17) (HHV-1) (Human Herpes Simplex Virus 1)
Not Available
6258156 ;  2839594 ;  7628623 ;  7552712 ;  9336833 ;  9715911 ;  9989588 ;  11056041 
Various pathway(s) in which protein is involved
vg:24271467
Not Available
MASYPCHQHASAFDQAARSRGHNNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANI
YTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPG
TNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN
376
Not Available
Not Available
15-07-1998
Evidence at protein level
Amino Acid Count % Frequency Amino Acid Count % Frequency
Alanine (A) Leucine (L)
Arginine (R) Lysine (K)
Asparagine (N) Methionine (M)
Aspartic Acid (D) Phenylalanine (F)
Cysteine (C) Proline (P)
Glutamine (Q) Serine (S)
Glutamic Acid (E) Threonine (T)
Glycine (G) Tryptophan (W)
Histidine (H) Tyrosine (Y)
Isoleucine (I) Valine (V)
% Number of Residues in Helices % Number of Residues in Strands % Number of Residues in Coils
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
2.7.1.21  
GO:0004797  ;   GO:0005524  ;   GO:0006230  ;   GO:0071897  
Not Available
Not Available
Not Available
X-ray crystallography (33)
1E2H  1E2I  1E2J  1E2K  1E2L  1E2M  1E2N  1E2P  1KI2  1KI3  1KI4  1KI6  1KI7  1KI8  1KIM  
1OF1  1P7C  1QHI  1VTK  2KI5  2VTK  3F0T  3RDP  3VTK  4IVP  4IVQ  4IVR  4JBX  4JBY  4OQL  
4OQM  4OQN  4OQX  
ACT_SITE 83 83 Proton acceptor.
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
DB02921      DB03804      DB03312      DB02324      DB02500      DB04139      DB02495      DB00787      DB04485      DB01004      DB03280      DB01643            
Not Applicable