Results | viHumans

UniProt ID

O72737

Status

Reviewed

Host

Bos Taurus (Bovine) [TaxID: 9913]; Felis Catus (Cat) (Felis Silvestris Catus) [TaxID: 9685]; Homo Sapiens (Human) [TaxID: 9606]; Loxodonta Africana (African Elephant) [TaxID: 9785]; Microtus Agrestis (Short-tailed Field Vole) [TaxID: 29092]; Mus Musculus (Mouse) [TaxID: 10090]; Myodes Glareolus (Bank Vole) (Clethrionomys Glareolus) [TaxID: 447135]

Gene Name

HA A58R

Protein Name

Protein A56 (Hemagglutinin)

Organism Name

Cowpox Virus (strain GRI-90 / Grishak) (CPV)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Cowpox Virus (CPV)> Cowpox Virus (strain GRI-90 / Grishak) (CPV)

RefSeq

NC_003663.2 ; AF482758.2

PubMed ID

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MARLPILLLLISLVYSTPSPQTSKKIGDDATLSCNRNNTTDYVVMSAWYKEPNSIILLAAKSDVLYFDNYTKDKISYDSPYDDLVTTITIKSLTARDAGT
YVCAFFMTSTTNDTDKVDYEEYSTELIVNTDSESTIDIILSGSTHSPETSSEKPDYIDNSNCSSVFEIATPEPITDNEEDHTDVTYTSENINTVSTTSRE
STTDETPEPITDKEEDHTVTDTVSYTTVSTSSGIVTTKSTTDDADLYDTYNDNDTVPPTTVGGSTTSISNYKTKDFVEIFGITALIILSAVAIFCITYYI
CNKRSRKYKTENKV
						

Length

314

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-08-1998

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Prevents cell to cell fusion by interacting with and directing the viral K2 protein on the host plasma membrane. The A56-K2 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation. Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019031 ; GO:0033644 ; GO:0055036

Subcellular Location

♦ Virion membrane
♦ Single-pass type I membrane protein . Host membrane
♦ Single-pass type I membrane protein . Note=Component of extracellular enveloped virus (EEV) but not intracellular mature virus (IMV). Component of the outermost membrane of EEV.

Domain(s)

DOMAIN 17 121 Ig-like V-type.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available