Results | viHumans

UniProt ID

O72736

Status

Reviewed

Host

Bos Taurus (Bovine) [TaxID: 9913]; Felis Catus (Cat) (Felis Silvestris Catus) [TaxID: 9685]; Homo Sapiens (Human) [TaxID: 9606]; Loxodonta Africana (African Elephant) [TaxID: 9785]; Microtus Agrestis (Short-tailed Field Vole) [TaxID: 29092]; Mus Musculus (Mouse) [TaxID: 10090]; Myodes Glareolus (Bank Vole) (Clethrionomys Glareolus) [TaxID: 447135]

Gene Name

KBTB1 A57R

Protein Name

Kelch repeat and BTB domain-containing protein 1

Organism Name

Cowpox Virus (strain GRI-90 / Grishak) (CPV)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Cowpox Virus (CPV)> Cowpox Virus (strain GRI-90 / Grishak) (CPV)

RefSeq

NC_003663.2 ; AF482758.2

PubMed ID

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MNNSSELIAVINGFRNSGRFCDINIVINDERINAHRLILSGASEYFSILFSNNFIDSNEYEVNLSHLDYQSVNDLIDYIYGIPLSLTNDNVKYILSTADF
LQIGSAITECEKYILKNLCSRNCIDFYIYADKYNNKKIESASFNTILRNILRLINDENFKYLTEESMIKILSDDMLNIKNEDFAPLILIKWLESTQQSCT
VELLRCLRISLLSPQVIKSLYSHQLVSSIYECITFLNNIAFLDESFPRYHSIELISIGISNSHDKISINCYNHKKNTWEMISSRRYRCSFAVAVLDNIIY
MMGGYDQSPYRSSKVIAYNTCTNSWIYDIPELKYPRSNCGGLADDEYIYCIGGIRDQDSSLTSSIDRWKPSKPYWQKYAKMREPKCDMGVAMLNGLIYVI
GGIVKGDTCTDALESLSEDGWMKHQRLPIKMSNMSTIVHDGKIYISGGYNNSSVVNVISNLVLSYNPIYDEWTKLSSLNIPRINPALWSAHNKLYVGGGI
SDDVRTNTSETYDKEKDCWTLDNGHVLPRNYIMYKCEPIKHKYPLEKTQYTNDFLKYLESFIGS
						

Length

564

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-08-1998

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.

EC

Not Available

Experimentally known GO terms

GO:0030430 ; GO:0039649

Subcellular Location

Host cytoplasm .

Domain(s)

♦DOMAIN 21 88 BTB.
♦ DOMAIN 123 219 BACK.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available