Results | viHumans

UniProt ID

O57178

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

MVA042L ACAM3000_MVA_042 F12L

Protein Name

Protein F12

Organism Name

Vaccinia Virus (strain Ankara) (VACV)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Vaccinia Virus> Vaccinia Virus (strain Ankara) (VACV)

RefSeq

NC_006998.1 ; AY243312.1

PubMed ID

9601507 ;

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MLNRIQTLMKTANNYETIEILRNYLRLYIILARNEEGHGILIYDDNIDSVMSMMNITILEVIGLTTHCTKLRSSPPIPMSRLFMDEIDHESYYSPKTSDY
PLIDIIRKRSHEQGDIALALERYGIENTDSISEINEWLSSKGLACYRFVKFNDYRKQMYRKFSRCTIVDSMIIGHIGHHYIWIKNLETYTRPEIDVLPFD
IKYISRDELWARISSSLDQTHIKTIAVSVYGAITDNGPIPYMISTYPGNTFVNFNSVKNLILNFLDWIKDIMTSTRTIILVGYMSNLFDIPLLTVYWPNN
CGWKIYNNTLISSDGARVIWMDAYKFSCGLSLQDYCYHWGSKPESRPFDLIKKSDAKRNSKSLVKESMASLKSLYEAFETQSGALEVLMSPCRMFSFSRI
EDMFLTSVINRVSENTGMGMYYPTNDIPSLFIESSICLDYIIVNNQESNKYRIKSVLDIISSKQYPAGRPNYVKNGTKGKLYIALCKVTVPTNDHIPVVY
HDDDNTTTFITVLTSVDIETAIRAGYSIVELGALQWDNNIPELKNGLLDSIKMIYDLNAVTTNNLLEQLIENINFNNSSIISLFYTFAISYCRAFIYSIM
ETIDPVYISQFSYKELYVSSSYKDINESMSQMVKL
						

Length

635

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-1998

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Late protein that plays a role in intracellular enveloped virus (IEV) transport to the cell surface on microtubules. When absent, viral morphogenesis halts after the formation of IEV particles, and these are not transported to the cell periphery. Important for plaque formation, extracellular envelope virus (EEV) production and virulence (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0009405 ; GO:0016032 ; GO:0044174 ; GO:0055036

Subcellular Location

Virion membrane . Host endosome . Note=Associates with the membrane of IEV particles, but not intracellular mature virus (IMV), cell-associated enveloped virus (CEV) or EEV. Colocalizes with microtubules (By similarity). .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available