Results | viHumans

UniProt ID

O40627

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Not Available

Protein Name

Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

Organism Name

Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)

Taxonomic Lineage

Viruses> DsRNA Viruses> Reoviridae> Sedoreovirinae> Rotavirus> Rotavirus A> Rotavirus G1> Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)

RefSeq

NC_011500.2 ; NC_011501.2 ; NC_011502.2 ; NC_011503.2 ; NC_011504.2 ; NC_011505.2 ; NC_011506.2 ;
NC_011507.2 ; NC_011508.2 ; NC_011509.2 ; NC_011510.2 ; NC_011511.2

PubMed ID

8629937

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MATFKDACYHYKRINKLNNNSLKLGVNDTWRPSPPTKYKGWCLDCCQHTDLTYCSGCTMYHVCQWCSQYGRCFLDNEPHLLRMRTFKNEVTKDDLKNLID
MYETLFPMNHKIVCRFINTARQHKCRNECMTQWYNHLLMPITLQSLSIELDGDVYYVFGYYDNMNNINQTPFSFINLVDIYDKLLLDDVNFTRMSFLPAS
LQQEYALRYFSKSRFINEQRKCVNDSHFSINVLENLHNPSFKIQITRNCSELSFDWNEACKLVKNVSAYFDMLKTSHIEFYSVSTRCRIFTQCKLKMASK
LIKPNYITSNHKTLATEVHNCKWCSVNNSYTVWNDFRIKKIYDNIFNFLRALVKSNVNIGHCSSQEKIYEYVKDVLNVCDDERWKTSIMEIFNCLEPVEL
DDVKYVLFNHEINWDVINVLVHSIGKVPQILTLENVITIMQSIIYEWFDIRYMRNTPMVTFTIDKLRRLYTGLKTVEYDSGISDIE
						

Length

486

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-01-1998

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities. Recognizes the host NF-kappa-B regulator BTRC through the presence of a DSGXS motif in the C-terminal substrate recognition domain.

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0030430 ; GO:0039548 ; GO:0039557 ; GO:0039644 ;
GO:0044163 ; GO:0046872

Subcellular Location

Host cytoplasm, host cytoskeleton .

Domain(s)

Not Available

Motif(s)

MOTIF 479 483 IKBKB-like degron (ILD) motif.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available