Reviewed
Homo Sapiens (Human) [TaxID: 9606]
L[Gene ID: 1489827 ]
♦RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ mRNA guanylyltransferase (EC 2.7.7.-)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ mRNA guanylyltransferase (EC 2.7.7.-)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)]
Human Respiratory Syncytial Virus B (strain B1)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Pneumoviridae> Orthopneumovirus> Human Respiratory Syncytial Virus> Human Respiratory Syncytial Virus B> Human Respiratory Syncytial Virus B (strain B1)
Not Available
Various pathway(s) in which protein is involved
Not Available
MDPIINGNSANVYLTDSYLKGVISFSECNALGSYLFNGPYLKNDYTNLISRQSPLLEHMNLKKLTITQSLISRYHKGELKLEEPTYFQSLLMTYKSMSSS
EQIATTNLLKKIIRRAIEISDVKVYAILNKLGLKEKDRVKPNNNSGDENSVLTTIIKDDILSAVESNQSYTNSDKNHSVNQNITIKTTLLKKLMCSMQHP
PSWLIHWFNLYTKLNNILTQYRSNEVKSHGFILIDNQTLSGFQFILNQYGCIVYHKGLKKITTTTYNQFLTWKDISLSRLNVCLITWISNCLNTLNKSLG
LRCGFNNVVLSQLFLYGDCILKLFHNEGFYIIKEVEGFIMSLILNITEEDQFRKRFYNSMLNNITDAAIKAQKNLLSRVCHTLLDKTVSDNIINGKWIIL
LSKFLKLIKLAGDNNLNNLSELYFLFRIFGHPMVDERQAMDAVRINCNETKFYLLSSLSTLRGAFIYRIIKGFVNTYNRWPTLRNAIVLPLRWLNYYKLN
TYPSLLEITENDLIILSGLRFYREFHLPKKVDLEMIINDKAISPPKDLIWTSFPRNYMPSHIQNYIEHEKLKFSESDRSRRVLEYYLRDNKFNECDLYNC
VVNQSYLNNSNHVVSLTGKERELSVGRMFAMQPGMFRQIQILAEKMIAENILQFFPESLTRYGDLELQKILELKAGISNKSNRYNDNYNNYISKCSIITD
LSKFNQAFRYETSCICSDVLDELHGVQSLFSWLHLTIPLVTIICTYRHAPPFIKDHVVNLNEVDEQSGLYRYHMGGIEGWCQKLWTIEAISLLDLISLKG
KFSITALINGDNQSIDISKPVRLIEGQTHAQADYLLALNSLKLLYKEYAGIGHKLKGTETYISRDMQFMSKTIQHNGVYYPASIKKVLRVGPWINTILDD
FKVSLESIGSLTQELEYRGESLLCSLIFRNIWLYNQIALQLRNHALCNNKLYLDILKVLKHLKTFFNLDSIDMALSLYMNLPMLFGGGDPNLLYRSFYRR
TPDFLTEAIVHSVFVLSYYTGHDLQDKLQDLPDDRLNKFLTCVITFDKNPNAEFVTLMRDPQALGSERQAKITSEINRLAVTEVLSIAPNKIFSKSAQHY
TTTEIDLNDIMQNIEPTYPHGLRVVYESLPFYKAEKIVNLISGTKSITNILEKTSAIDTTDINRATDMMRKNITLLIRILPLDCNKDKRELLSLENLSIT
ELSKYVRERSWSLSNIVGVTSPSIMFTMDIKYTTSTIASGIIIEKYNVNSLTRGERGPTKPWVGSSTQEKKTMPVYNRQVLTKKQRDQIDLLAKLDWVYA
SIDNKDEFMEELSTGTLGLSYEKAKKLFPQYLSVNYLHRLTVSSRPCEFPASIPAYRTTNYHFDTSPINHVLTEKYGDEDIDIVFQNCISFGLSLMSVVE
QFTNICPNRIILIPKLNEIHLMKPPIFTGDVDIIKLKQVIQKQHMFLPDKISLTQYVELFLSNKALKSGSNINSNLILVHKMSDYFHNAYILSTNLAGHW
ILIIQLMKDSKGIFEKDWGEGYITDHMFINLNVFFNAYKTYLLCFHKGYGKAKLECDMNTSDLLCVLELIDSSYWKSMSKVFLEQKVIKYIVNQDTSLHR
IKGCHSFKLWFLKRLNNAKFTVCPWVVNIDYHPTHMKAILSYIDLVRMGLINVDKLTIKNKNKFNDEFYTSNLFYISYNFSDNTHLLTKQIRIANSELED
NYNKLYHPTPETLENISLIPVKSNNSNKPKFCISGNTESIMMSTFSNKMHIKSSTVTTRFNYSKQDLYNLFPNVVIDRIIDHSGNTAKSNQLYITTSHQT
SLVRNSASLYCMLPWHHVNRFNFVFSSTGCKISIEYILKDLKIKDPSCIAFIGEGAGNLLLRTVVELHPDIRYIYRSLKDCNDHSLPIEFLRLYNGHINI
DYGENLTIPATDATNNIHWSYLHIKFAEPISIFVCDAELPVTANWSKIIIEWSKHVRKCKYCSSVNRCILIAKYHAQDDIDFKLDNITILKTYVCLGSKL
KGSEVYLVLTIGPANILPVFDVVQNAKLIFSRTKNFIMPKKTDKESIDANIKSLIPFLCYPITKKGIKTSLSKLKSVVNGDILSYSIAGRNEVFSNKLIN
HKHMNILKWLDHVLNFRSAELNYNHLYMIESTYPYLSELLNSLTTNELKKLIKITGSVLYNLPNEQ
EQIATTNLLKKIIRRAIEISDVKVYAILNKLGLKEKDRVKPNNNSGDENSVLTTIIKDDILSAVESNQSYTNSDKNHSVNQNITIKTTLLKKLMCSMQHP
PSWLIHWFNLYTKLNNILTQYRSNEVKSHGFILIDNQTLSGFQFILNQYGCIVYHKGLKKITTTTYNQFLTWKDISLSRLNVCLITWISNCLNTLNKSLG
LRCGFNNVVLSQLFLYGDCILKLFHNEGFYIIKEVEGFIMSLILNITEEDQFRKRFYNSMLNNITDAAIKAQKNLLSRVCHTLLDKTVSDNIINGKWIIL
LSKFLKLIKLAGDNNLNNLSELYFLFRIFGHPMVDERQAMDAVRINCNETKFYLLSSLSTLRGAFIYRIIKGFVNTYNRWPTLRNAIVLPLRWLNYYKLN
TYPSLLEITENDLIILSGLRFYREFHLPKKVDLEMIINDKAISPPKDLIWTSFPRNYMPSHIQNYIEHEKLKFSESDRSRRVLEYYLRDNKFNECDLYNC
VVNQSYLNNSNHVVSLTGKERELSVGRMFAMQPGMFRQIQILAEKMIAENILQFFPESLTRYGDLELQKILELKAGISNKSNRYNDNYNNYISKCSIITD
LSKFNQAFRYETSCICSDVLDELHGVQSLFSWLHLTIPLVTIICTYRHAPPFIKDHVVNLNEVDEQSGLYRYHMGGIEGWCQKLWTIEAISLLDLISLKG
KFSITALINGDNQSIDISKPVRLIEGQTHAQADYLLALNSLKLLYKEYAGIGHKLKGTETYISRDMQFMSKTIQHNGVYYPASIKKVLRVGPWINTILDD
FKVSLESIGSLTQELEYRGESLLCSLIFRNIWLYNQIALQLRNHALCNNKLYLDILKVLKHLKTFFNLDSIDMALSLYMNLPMLFGGGDPNLLYRSFYRR
TPDFLTEAIVHSVFVLSYYTGHDLQDKLQDLPDDRLNKFLTCVITFDKNPNAEFVTLMRDPQALGSERQAKITSEINRLAVTEVLSIAPNKIFSKSAQHY
TTTEIDLNDIMQNIEPTYPHGLRVVYESLPFYKAEKIVNLISGTKSITNILEKTSAIDTTDINRATDMMRKNITLLIRILPLDCNKDKRELLSLENLSIT
ELSKYVRERSWSLSNIVGVTSPSIMFTMDIKYTTSTIASGIIIEKYNVNSLTRGERGPTKPWVGSSTQEKKTMPVYNRQVLTKKQRDQIDLLAKLDWVYA
SIDNKDEFMEELSTGTLGLSYEKAKKLFPQYLSVNYLHRLTVSSRPCEFPASIPAYRTTNYHFDTSPINHVLTEKYGDEDIDIVFQNCISFGLSLMSVVE
QFTNICPNRIILIPKLNEIHLMKPPIFTGDVDIIKLKQVIQKQHMFLPDKISLTQYVELFLSNKALKSGSNINSNLILVHKMSDYFHNAYILSTNLAGHW
ILIIQLMKDSKGIFEKDWGEGYITDHMFINLNVFFNAYKTYLLCFHKGYGKAKLECDMNTSDLLCVLELIDSSYWKSMSKVFLEQKVIKYIVNQDTSLHR
IKGCHSFKLWFLKRLNNAKFTVCPWVVNIDYHPTHMKAILSYIDLVRMGLINVDKLTIKNKNKFNDEFYTSNLFYISYNFSDNTHLLTKQIRIANSELED
NYNKLYHPTPETLENISLIPVKSNNSNKPKFCISGNTESIMMSTFSNKMHIKSSTVTTRFNYSKQDLYNLFPNVVIDRIIDHSGNTAKSNQLYITTSHQT
SLVRNSASLYCMLPWHHVNRFNFVFSSTGCKISIEYILKDLKIKDPSCIAFIGEGAGNLLLRTVVELHPDIRYIYRSLKDCNDHSLPIEFLRLYNGHINI
DYGENLTIPATDATNNIHWSYLHIKFAEPISIFVCDAELPVTANWSKIIIEWSKHVRKCKYCSSVNRCILIAKYHAQDDIDFKLDNITILKTYVCLGSKL
KGSEVYLVLTIGPANILPVFDVVQNAKLIFSRTKNFIMPKKTDKESIDANIKSLIPFLCYPITKKGIKTSLSKLKSVVNGDILSYSIAGRNEVFSNKLIN
HKHMNILKWLDHVLNFRSAELNYNHLYMIESTYPYLSELLNSLTTNELKKLIKITGSVLYNLPNEQ
2166
Not Available
Not Available
01-01-1998
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).
2.7.7.48 , 2.1.1.56 , 2.7.7.- , 2.7.7.88
Virion . Host cytoplasm .
♦DOMAIN 693 877 RdRp catalytic.
♦ DOMAIN 1820 2008 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1820 2008 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available