Reviewed
Homo Sapiens (Human) [TaxID: 9606]
TRM3 ORF29[Gene ID: 4961443 ]
Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)
Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Rhadinovirus> Human Herpesvirus 8 (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)> Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)
Various pathway(s) in which protein is involved
Not Available
MLLSRHRERLAANLQETAKDAGERWELSAPTFTRHCPKTARMAHPFIGVVHRINSYSSVLETYCTRHHPATPTSANPDVGTPRPSEDNVPAKPRLLESLS
TYLQMRCVREDAHVSTADQLVEYQAARKTHDSLHACSVYRELQAFLVNLSSFLNGCYVPGVHWLEPFQQQLVMHTFFFLVSIKAPQKTHQLFGLFKQYFG
LFETPNSVLQTFKQKASVFLIPRRHGKTWIVVAIISMLLASVENINIGYVAHQKHVANSVFAEIIKTLCRWFPPKNLNIKKENGTIIYTRPGGRSSSLMC
ATCFNKNSIRGQTFNLLYVDEANFIKKDALPAILGFMLQKDAKLIFISSVNSSDRSTSFLLNLRNAQEKMLNVVSYVCADHREDFHLQDALVSCPCYRLH
IPTYITIDESIKTTTNLFMEGAFDTELMGEGAASSNATLYRVVGDAALTQFDMCRVDTTAQQVQKCLGKQLFVYIDPAYTNNTEASGTGVGAVVTSTQTP
TRSLILGMEHFFLRDLTGAAAYEIASCACTMIKAIAVLHPTIERVNAAVEGNSSQDSGVAIATVLNEICPLPIHFLHYTDKSSALQWPIYMLGGEKSSAF
ETFIYALNSGTLSASQTVVSNTIKISFDPVTYLVEQVRAIKCVPLRDGGQSYSAKQKHMSDDLLVAVVMAHFMATDDRHMYKPISPQ
TYLQMRCVREDAHVSTADQLVEYQAARKTHDSLHACSVYRELQAFLVNLSSFLNGCYVPGVHWLEPFQQQLVMHTFFFLVSIKAPQKTHQLFGLFKQYFG
LFETPNSVLQTFKQKASVFLIPRRHGKTWIVVAIISMLLASVENINIGYVAHQKHVANSVFAEIIKTLCRWFPPKNLNIKKENGTIIYTRPGGRSSSLMC
ATCFNKNSIRGQTFNLLYVDEANFIKKDALPAILGFMLQKDAKLIFISSVNSSDRSTSFLLNLRNAQEKMLNVVSYVCADHREDFHLQDALVSCPCYRLH
IPTYITIDESIKTTTNLFMEGAFDTELMGEGAASSNATLYRVVGDAALTQFDMCRVDTTAQQVQKCLGKQLFVYIDPAYTNNTEASGTGVGAVVTSTQTP
TRSLILGMEHFFLRDLTGAAAYEIASCACTMIKAIAVLHPTIERVNAAVEGNSSQDSGVAIATVLNEICPLPIHFLHYTDKSSALQWPIYMLGGEKSSAF
ETFIYALNSGTLSASQTVVSNTIKISFDPVTYLVEQVRAIKCVPLRDGGQSYSAKQKHMSDDLLVAVVMAHFMATDDRHMYKPISPQ
687
Not Available
Not Available
28-06-2011
Inferred from homology
Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
---|---|---|---|---|---|
Alanine (A) | Leucine (L) | ||||
Arginine (R) | Lysine (K) | ||||
Asparagine (N) | Methionine (M) | ||||
Aspartic Acid (D) | Phenylalanine (F) | ||||
Cysteine (C) | Proline (P) | ||||
Glutamine (Q) | Serine (S) | ||||
Glutamic Acid (E) | Threonine (T) | ||||
Glycine (G) | Tryptophan (W) | ||||
Histidine (H) | Tyrosine (Y) | ||||
Isoleucine (I) | Valine (V) |
% Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
---|---|---|
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
3.1.-.-
Host nucleus . Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2. .
Not Available
MOTIF 221 228 Walker A motif. ; MOTIF 316 321 Walker B motif.
Predicted/Modelled
Not Available
♦ACT_SITE 321 321 For ATPase activity.
♦ ACT_SITE 476 476 For nuclease activity.
♦ ACT_SITE 550 550 For nuclease activity.
♦ ACT_SITE 662 662 For nuclease activity.
♦ ACT_SITE 476 476 For nuclease activity.
♦ ACT_SITE 550 550 For nuclease activity.
♦ ACT_SITE 662 662 For nuclease activity.
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available