Results | viHumans

UniProt ID

F5HFQ0

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

GN ORF53[Gene ID: 4961468 ]

Protein Name

Envelope glycoprotein N

Organism Name

Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Rhadinovirus> Human Herpesvirus 8 (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)> Human Herpesvirus 8 Type P (isolate GK18) (HHV-8) (Kaposi's Sarcoma-associated Herpesvirus)

RefSeq

NC_009333.1 ; AF148805.2

PubMed ID

10400794 ; 16760382 ; 12771417

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:4961468

Reactome

Not Available

Sequence

							MTASTVALALFVASILGHCWVTANSTGVASSTERSSPSTAGLSARPSPGPTSVTTPGFYDVACSADSFSPSLSSFSSVWALINALLVVVATFFYLVYLCF
FKFVDEVVHA
						

Length

110

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

28-06-2011

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Plays also a critical role in virion morphogenesis.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019031 ; GO:0033644 ; GO:0044177 ; GO:0055036

Subcellular Location

♦ Virion membrane ,
♦ Single-pass type I membrane protein , . Host membrane
♦ Single-pass type I membrane protein , . Host Golgi apparatus, host trans-Golgi network . Note=When coexpressed with gM, localizes in the host trans-Golgi network. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available