Results | viHumans

UniProt ID

F5HFA5

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

UL117[Gene ID: 3077511 ]

Protein Name

Protein UL117 (pUL117)

Organism Name

Human Cytomegalovirus (strain Merlin) (HHV-5) (Human Herpesvirus 5)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Betaherpesvirinae> Cytomegalovirus> Human Cytomegalovirus (HHV-5) (Human Herpesvirus 5)> Human Cytomegalovirus (strain Merlin) (HHV-5) (Human Herpesvirus 5)

RefSeq

Not Available

PubMed ID

15105547

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:3077511

Reactome

Not Available

Sequence

							MVMFSQDHVQIVYGSTRICKSLAPANKRKTHRTIVVAPRRGFLRIPPDGQDVNHVKIVPTTTSSSLAPPRDDERRPTPPLRPPLTVYPYGTSLIRRSARD
AKLRSKLIVFHITRPALGQHPQNPGISGPAAMDHSEFLTSFRREVDRQTVLTAESAPATVEVCLGDALPGGVMGGGGLPAGVGSASAAVAAAAAAVAGVP
VAANPVMPATATVTTPPMIDLTSHHRPLTLFTPASAAAAPAVATNGGNATYILPADCRYAPLFASKYKYVFEEVSRLMRLHDSTAVQLQISASCGNAFQA
LKSALLKLHNVTVLAGQQLITQTMPHTPQAVATFKFFHQDPNRVLDCIRPVVPRSTSYHETGVYQMWVSGATKKDLFDAVTLCASIVEKQPDVFNINVSL
LTYPSIAAPHLPLYNEFTSFRLPTS
						

Length

425

Alternate Sequence

VAR_SEQ 1 131 Missing (in isoform UL1175)

Non-standard residue

Not Available

Date of last Sequence modification

28-06-2011

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a role in the inhibition of host DNA replication in the infected cell. Targets the mini-chromosome maintenance (MCM) complex and blocks the accumulation of MCM proteins and their loading onto host chromatin (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0006355 ; GO:0042025

Subcellular Location

♦ Isoform UL117: Host nucleus . Note=The major fraction localizes to nuclear compartments. .
♦ Isoform UL117.5: Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available