Reviewed
Homo Sapiens (Human) [TaxID: 9606]
Z[Gene ID: 6216306 ]
RING finger protein Z (Protein Z) (Zinc-binding protein)
Chapare Mammarenavirus (isolate Human/Bolivia/810419/2003)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Arenaviridae> Mammarenavirus> Chapare Mammarenavirus (isolate Human/Bolivia/810419/2003)
Various pathway(s) in which protein is involved
Not Available
MGNTKTKDRQYQSNSSQPTNTSAPVLLRRQAEPSLYGRHNCRCCWFADTNLVNCSNHYLCLKCLNTMLRRSNLCDICGEELPTTIIVPVEPSAPLPGQ
98
Not Available
Not Available
20-05-2008
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E.
Not Available
♦ Virion . Host cytoplasm, host perinuclear region . Host cell membrane
♦ Lipid-anchor
♦ Cytoplasmic side . Note=Mainly perinuclear. During budding, associates at the inner side of the plasma membrane of infected cells. .
♦ Lipid-anchor
♦ Cytoplasmic side . Note=Mainly perinuclear. During budding, associates at the inner side of the plasma membrane of infected cells. .
Not Available
MOTIF 91 94 PTAP/PSAP motif.
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available