Reviewed
Homo Sapiens (Human) [TaxID: 9606]
N[Gene ID: 6216303 ]
Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Chapare Mammarenavirus (isolate Human/Bolivia/810419/2003)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Arenaviridae> Mammarenavirus> Chapare Mammarenavirus (isolate Human/Bolivia/810419/2003)
Various pathway(s) in which protein is involved
Not Available
MSNSKEIPSFRWTQSLRRELSSFTIPVKSDVLKDAKMIADGLDFSQVALVQRVLRKTKRTDGDLDKLRDLNREVDNLMAMKSAQKNTILKLGDLNKSELM
DLASDLEKLKKKVGQTERSPVGGVYLGNLSQSQLSKRTDLLRRLGFQQPQVRSTGVVRIWDVADPTRLNNQFGSVPALTIACMTVQGGDTMGNVVQALTS
LGLLYTVKFPNLADLEKLAAEHDCLQIITKDESAINISGYNFSLSAAVKAGATFLDGGNMLETIKVTPDNFSTIIKTVLGVKKRENMFIDERPGNRNPYE
NLLYKLCLSGEGWPYIGSRSQVKGRSWENTTVDLSLKPTQGPKAPEKVGLNVRLSHLTEIQESVVREAMSKINPSHTTWIDIEGTSNDPVELALYQPESG
NYILCYRKPHDEKGFKNGSRHSHGMLLKDLESAQPGLLSYIIGLLPQDMVLTAQGSDDIKRLLDTHGRKDLKVVDVKLSSDQARNYEEQVWSDFGHLCKK
HNGVVVPKKKKDKDPSQSTEPHCALLDCLMFQSVIDGQPPQIKLQSLLPEVLLFTMKPAFAI
DLASDLEKLKKKVGQTERSPVGGVYLGNLSQSQLSKRTDLLRRLGFQQPQVRSTGVVRIWDVADPTRLNNQFGSVPALTIACMTVQGGDTMGNVVQALTS
LGLLYTVKFPNLADLEKLAAEHDCLQIITKDESAINISGYNFSLSAAVKAGATFLDGGNMLETIKVTPDNFSTIIKTVLGVKKRENMFIDERPGNRNPYE
NLLYKLCLSGEGWPYIGSRSQVKGRSWENTTVDLSLKPTQGPKAPEKVGLNVRLSHLTEIQESVVREAMSKINPSHTTWIDIEGTSNDPVELALYQPESG
NYILCYRKPHDEKGFKNGSRHSHGMLLKDLESAQPGLLSYIIGLLPQDMVLTAQGSDDIKRLLDTHGRKDLKVVDVKLSSDQARNYEEQVWSDFGHLCKK
HNGVVVPKKKKDKDPSQSTEPHCALLDCLMFQSVIDGQPPQIKLQSLLPEVLLFTMKPAFAI
562
Not Available
Not Available
20-05-2008
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and therby participates in the suppression of interferon induction.
3.1.13.-
GO:0003723 ; GO:0016787 ; GO:0019013 ; GO:0019029 ; GO:0030430 ;
GO:0039689 ; GO:0039696 ; GO:0039724 ; GO:0046872
GO:0039689 ; GO:0039696 ; GO:0039724 ; GO:0046872
Virion . Host cytoplasm .
Not Available
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available