Introduction

Plasmodium vivax is one of the five species of malaria parasites that commonly infect humans and the most common cause of frequent malaria. It is less virulent than Plasmodium falciparum, the deadliest of the five, but vivax malaria can lead to severe disease and death. P. vivax is carried by the female Anopheles mosquito. The genome is 22 MB in size; the GC content is 45% (unlike some other Plasmodia sequences, which have notably low GC content) and about 5000 genes have been predicted. (Carlton et al., 2001). P. vivax nuclear DNA is distributed between 14 linear chromosomes that range in size from 1.2 to 3.5 Mb (Carlton, et al., 1999). Currently we have overall only 1% experimental protein structures in PDB.

PvaxDB database is a source of more than 500 P.Vivax predicted protein structures which include some RBC invasion and other globular proteins . Each predicted protein model have strucutre analysis result with ProtSAV metaserver along with their predicted protein functions and protein sequence.

List Of Predicted Protein Models

References

1. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P et al. 2008. Nature. 455:757-763. 


2. Karyotype and synteny among the chromosomes of all four species of human malaria parasite Carlton JM, Galinski MR, Barnwell JW, Dame JB. 1999 Mol Biochem Parasitol. Jun 25; 101(1-2):23-32

3. Jayaram B, Dhingra P, Mishra A, Kaushik R, Mukherjee G, Singh A , Shekhar S. Bhageerath-H: A homology/ ab initio hybrid server for predicting tertiary BMC Bioinformatics 2014, 15(Suppl 16), S7.

4. Ankita Singh, Rahul Kaushik, Avinash Mishra, Asheesh Shankar Sharma, B.Jayaram. ProTSAV: Protein Tertiary Structure Analysis and Validation.[Under Revision]

5.Das Gupta D. Kaushik R. Jayaram B.From Ramachandran maps to tertiary structures of proteins. (Submitted)