S2F is a refined and improved amalgamation of several softwares for protein function prediction which are based on different sequence-based approaches. The metaserver provides a single platform to the users to get functional insights of a query protein through different sources like DeepGo, PFP, STRING, Eggnog, InterProScan, Pannzer2 and Seq2Func. This way a user will not miss the opportunity of finding possible functions for a protein sequence. S2F provides the maximum GO terms with high confidence to the users.