Plasmodium vivax is one of the five species of malaria parasites that commonly infect humans and the most common cause of frequent malaria. It is less virulent than Plasmodium falciparum, the deadliest of the five, but vivax malaria can lead to severe disease and death. P. vivax is carried by the female Anopheles mosquito. The genome is 22 MB in size; the GC content is 45% (unlike some other Plasmodia sequences, which have notably low GC content) and about 5000 genes have been predicted. (Carlton et al., 2001). P vivax nuclear DNA is distributed between 14 linear chromosomes that range in size from 1.2 to 3.5 Mb (Carlton, et al., 1999). Currently we have overall only 1% experimental protein structures in PDB.
Annotation
Annotation for the Plasmodium_vivax genomes has been derived from annotation submitted to the EMBL/Genbank/DDBJ databases; and enhanced by importing data from additional sources, principally UniProtKB and GOA.
References
1. Comparative genomics of the neglected human malaria parasite Plasmodium vivax.
Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P et al. 2008. Nature. 455:757-763.
2.Karyotype and synteny among the chromosomes of all four species of human malaria parasite
Carlton JM, Galinski MR, Barnwell JW, Dame JB. 1999 Mol Biochem Parasitol. Jun 25; 101(1-2):23-32
