Results | viHumans

UniProt ID

Q86607

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

VGF

Protein Name

Pro-vaccinia growth factor (Pro-VGF) [Cleaved into: Vaccinia growth factor (VGF) (Secreted epidermal growth factor-like)]

Organism Name

Vaccinia Virus (strain L-IVP) (VACV)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Vaccinia Virus> Vaccinia Virus (strain L-IVP) (VACV)

RefSeq

NC_006998.1 ; AY243312.1

PubMed ID

1298881

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSMKYLMLLFAAMIIRSFADSGNAIETTLPEITNATTDIPAIRLCGPEGDGYCLHGDCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSENPNTTTSY
IPSPGIVLVLVGIIIITCCSLSVYRFTRRTKLPIQDMVVP
						

Length

140

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-11-1996

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Vaccinia growth factor stimulates cellular proliferation (hyperplasia) around infected cells. This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells. Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival. The activation by host EFGR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0005154 ; GO:0005576 ; GO:0007176 ; GO:0008083 ; GO:0016021 ;
GO:0016032 ; GO:0033644

Subcellular Location

♦ Pro-vaccinia growth factor: Host membrane
♦ Single-pass type I membrane protein .
♦ Vaccinia growth factor: Secreted .

Domain(s)

DOMAIN 41 81 EGF-like.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available