Reviewed
Calomys Callosus (Large Vesper Mouse) [TaxID: 56210]; Chlorocebus Aethiops (Green Monkey) (Cercopithecus Aethiops) [TaxID: 9534]; Homo Sapiens (Human) [TaxID: 9606]
L
RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) (Replicase) (Transcriptase)
Machupo Virus (MACV)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Arenaviridae> Mammarenavirus> Machupo Virus (MACV)
Various pathway(s) in which protein is involved
Not Available
Not Available
MDEYVQELKGLIRKHIPDRCEFAHQKVTFLSQVHPSPLLTEGFKLLSSLVELESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLIL
LETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRFVADWVIERMRWLLIEILKASKSMLEIDIEDQEYQRLIHSLSNVKNQSLG
LENLEHLKRNSLDYDERLNESLFIGLKGDIRESTVREELIKLKMWFKDEVFSKGLGKFKLTDRRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTF
SSVERTDGAATVDQQFSTTHTNIEKHYLSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISESCQDAIESLRKSGLIVGQMVMLVNDRVLDILEAI
KLIRKKIGTNPNWVKNCSKILERSHPEIWLQLNTLIRQPDFNSLISIAQYLVSDRPIMRYSVERGSDKICRHKLFQEMSSFEQMRLFKTLSSISLSLINS
MKTSFSSRLLVNEREFSKYFGNVRLRECYAQRFYLAESLVGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLAGMCEEMTSWLD
FDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFLMAFANQIHHIDLISKLVVECKSSSEVVVQRLAVGLFIRLLGGESDASSFFSRRFKYLLNVS
YLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPSLNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNRGKLKVSGELKN
NPFRPNITSTALDLSSNKSVVIPKLDELGNILSTYDKEKLVSACVSSMAERFKTKGRYNLDPESTDYLILKNLTGLVSAGPKAKSSQEELSLMYETLTEE
QVESFNEIKYDVQVALAKMADNSVNTRIKNLGRADNSVKNGNNPLDNLWSPFGVMKEIRAEVSLHEVKDFDPDVLPSDVYKELCDAVYKSSEKCNFFLEE
VLDVCPLGLLLKNLTTSSYMEEEYFMCFKYLLIQGHFDQKLGSYEHKSRSRLGFTDETLRLKDEVRLSIRESNSEAIADKLDKSYFTNAALRNLCFYSED
SPTEFTSISSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKWGPTMSPAL
FLALLQMLELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINVAEAYCIGKLKRSLGLMGCGSTSLSEEFFHQTMQLSGQIPSHIMSVLDMGQGILHNTSD
LYGLITEQFLCYALDLLYDVIPVSYTSSDDQITLVKTPSLDIEGGSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFKSRFFVMGEETPLLTKFV
SAALHNVKCKTPTQLSETIDTICDQCIANGVSTKIVARISKRVNQLIRYSGYGDTPFGAIEDQDVKDWVDGSRGYRLQRKIEAIFYDDKETSFIRNCARK
VFNDIKRGRIFEENLINLIGRGGDEALTGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLVLRTKLMTSRRVLEREEVPTLIKTLQSKLSRNFTKGVKKI
LAESINKSAFQSSVASGFIGFCKSMGSKCVRDGKGGFLYIKEVYSGINVCICEICALKPKIIYCNDSLNKVSQFSKPILWDYFSLVLTNACELGEWVFST
VKEPQKPLVLNNQNFFWAVKPKVVRQIEDQLGMNHVLQSIRRNYPVLFDEHLAPFMNDLQVSRTMDSGRLKFLDVCIALDMMNENLGIISHLLKTRDNSV
YIVKQSDCALAHIRQSSYTDWELGLSPQQICTNFKTQLVLSSMVNPLVLSTSCLKSFFWFNEVLELEDDSQIELAELTDFALMVKNQNVSRAMFVEDIAM
GYVVSNFEGVRISLSNVMVDGVQLPPKEKAPDVGVLFGLKAENVIVGLVVQIDHVRMSTKFKLRRKMVYSFSLECTMDVGDIQNKEVILKVVAVDQSVSG
SGGNHMLLDGVPVIASLPLFTGQASFDLAAMLIESNLAGSNDNFLMSNVTLDLGGFSPELSDKYSYRLSGPENQEDPLVLKDGAFYVGGERLSTYKVELT
GDLVVKALGALEDDEGVVSMLHQLWPYLKATSQVILFQQEDFTIVHDLYKIQLTKSIESFGEWIEFTNFKVAYSKSLKELVISDTQGSFRLKGVMCRPLA
NTLQVEDIE
LETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRFVADWVIERMRWLLIEILKASKSMLEIDIEDQEYQRLIHSLSNVKNQSLG
LENLEHLKRNSLDYDERLNESLFIGLKGDIRESTVREELIKLKMWFKDEVFSKGLGKFKLTDRRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTF
SSVERTDGAATVDQQFSTTHTNIEKHYLSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISESCQDAIESLRKSGLIVGQMVMLVNDRVLDILEAI
KLIRKKIGTNPNWVKNCSKILERSHPEIWLQLNTLIRQPDFNSLISIAQYLVSDRPIMRYSVERGSDKICRHKLFQEMSSFEQMRLFKTLSSISLSLINS
MKTSFSSRLLVNEREFSKYFGNVRLRECYAQRFYLAESLVGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLAGMCEEMTSWLD
FDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFLMAFANQIHHIDLISKLVVECKSSSEVVVQRLAVGLFIRLLGGESDASSFFSRRFKYLLNVS
YLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPSLNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNRGKLKVSGELKN
NPFRPNITSTALDLSSNKSVVIPKLDELGNILSTYDKEKLVSACVSSMAERFKTKGRYNLDPESTDYLILKNLTGLVSAGPKAKSSQEELSLMYETLTEE
QVESFNEIKYDVQVALAKMADNSVNTRIKNLGRADNSVKNGNNPLDNLWSPFGVMKEIRAEVSLHEVKDFDPDVLPSDVYKELCDAVYKSSEKCNFFLEE
VLDVCPLGLLLKNLTTSSYMEEEYFMCFKYLLIQGHFDQKLGSYEHKSRSRLGFTDETLRLKDEVRLSIRESNSEAIADKLDKSYFTNAALRNLCFYSED
SPTEFTSISSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKWGPTMSPAL
FLALLQMLELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINVAEAYCIGKLKRSLGLMGCGSTSLSEEFFHQTMQLSGQIPSHIMSVLDMGQGILHNTSD
LYGLITEQFLCYALDLLYDVIPVSYTSSDDQITLVKTPSLDIEGGSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFKSRFFVMGEETPLLTKFV
SAALHNVKCKTPTQLSETIDTICDQCIANGVSTKIVARISKRVNQLIRYSGYGDTPFGAIEDQDVKDWVDGSRGYRLQRKIEAIFYDDKETSFIRNCARK
VFNDIKRGRIFEENLINLIGRGGDEALTGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLVLRTKLMTSRRVLEREEVPTLIKTLQSKLSRNFTKGVKKI
LAESINKSAFQSSVASGFIGFCKSMGSKCVRDGKGGFLYIKEVYSGINVCICEICALKPKIIYCNDSLNKVSQFSKPILWDYFSLVLTNACELGEWVFST
VKEPQKPLVLNNQNFFWAVKPKVVRQIEDQLGMNHVLQSIRRNYPVLFDEHLAPFMNDLQVSRTMDSGRLKFLDVCIALDMMNENLGIISHLLKTRDNSV
YIVKQSDCALAHIRQSSYTDWELGLSPQQICTNFKTQLVLSSMVNPLVLSTSCLKSFFWFNEVLELEDDSQIELAELTDFALMVKNQNVSRAMFVEDIAM
GYVVSNFEGVRISLSNVMVDGVQLPPKEKAPDVGVLFGLKAENVIVGLVVQIDHVRMSTKFKLRRKMVYSFSLECTMDVGDIQNKEVILKVVAVDQSVSG
SGGNHMLLDGVPVIASLPLFTGQASFDLAAMLIESNLAGSNDNFLMSNVTLDLGGFSPELSDKYSYRLSGPENQEDPLVLKDGAFYVGGERLSTYKVELT
GDLVVKALGALEDDEGVVSMLHQLWPYLKATSQVILFQQEDFTIVHDLYKIQLTKSIESFGEWIEFTNFKVAYSKSLKELVISDTQGSFRLKGVMCRPLA
NTLQVEDIE
2209
Not Available
Not Available
05-07-2004
Evidence at protein level
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.
2.7.7.48 , 3.1.-.-
GO:0000166 ; GO:0003968 ; GO:0016787 ; GO:0019012 ; GO:0030430 ;
GO:0039689 ; GO:0039696 ; GO:0075526
GO:0039689 ; GO:0039696 ; GO:0075526
Virion . Host cytoplasm .
DOMAIN 1172 1369 RdRp catalytic.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available