Reviewed
Homo Sapiens (Human) [TaxID: 9606]; Mammalia [TaxID: 40674]
L
♦Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48)
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
♦ mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)
♦ GDP polyribonucleotidyltransferase (EC 2.7.7.88)
♦ Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
Rabies Virus (strain Silver-haired Bat-associated) (RABV) (SHBRV)
Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Rhabdoviridae> Lyssavirus> Rabies Lyssavirus> Rabies Virus (strain Silver-haired Bat-associated) (RABV) (SHBRV)
Various pathway(s) in which protein is involved
Not Available
Not Available
MMIDPGEVYDDPIDLIESEAEPKGNPTIPNILRNSDYNLNSPLIEDPARLMLEWLKTGNRPLRMTLTDNCSRSHKVLKDYFKRVDLGSLKVGGAAAQSMI
SLWLYGAHSESNRSRKCINDLAQFYYKSSPIEKLLNCTLGNRGLKTPPEGVLSCLARVDYDKAFGRYLANIYSSYLFFHVITLYMNALDWDEEKTILALW
RDITSIDTGKDLVKFKDQIWGLLIVTKDFVYSQSTGCLFDRNYTLMLKDLFLSRFNSLMILLSPPEPRYSDDLISQLCQLYIAGDQVLSMCGNSGYEVIK
ILEPYVVNSLVQRAEKFRPLIHSLGDFPTFIRDKVGQLEGTFGPSAKRFFKVLDQFDNIHDLVFVYGCYRHWGHPYIDYRKGLSKLYDQVHLKKVIDKSY
QECLASDLARRILRWGFDKYSKWYLDSRLLSRDHPLIPYIKTQTWPPRHIVDLVGDTWHKLPITQIFEIPESMDPSEILDDKSHSFTRTRLASWLSENRG
GPVPSEKVIITALSKPPVNPREFLKSIDLGGLPDEDLIIGLKPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDR
VTGQGLLDYSRVTYAFRLDYEKWNNHQRLESTEDVFSVLDQVFGLKRVFSRTHEFFQRSWIYYSDRSDLIGLWEDQIYCLDMSDGPTCWNGQDGGLEGLR
QKGWSLVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSPGLSREGLLYELESISRNALSIYRAIEEGASKLGLIIKKEETMCSYDFLIYGKTPLFRG
NILVPESKRWARVSCISNDQIVNLANTMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSAEGDNFLLAMSRIIYLDPSLG
GVSGMSLGRFHIRQFSDPVSEGLSFWREIWLSSNESWIHALCQEAGNPDLGERTLESFTRLLEDPTTLNIKGGASPTILLKDAIRKALYDEVDEVENSEF
REAILLSKTHRDNFILFLKSIEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRRSLSRTLEESFYNSETHGINRMTQTPQRVGRVWPCSSERAD
LLREISWGRKVVGTTVPHPSEMLGLIPKSSISCTCGAAGGGNPRISVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRALSLKESI
NWFITRNSNRAQTLIRNIMSLTGPDFPLEEAPVFKRTGSALHRFKSARYSEGGYSSVCPNLLSHISVSTDTMSDLTQDGRNYDFMFQPLMLYAQTWTSEL
VQKDTRLKDSTFHWHLRCNKCIRPIDDMTLDTSQVFEFPDVSRRISRMVSGAVPHFRKLPDIRLRPGDFESLSGKEKSRHIGSAQGLLYSILVAIHDSGY
NDGTIFPVNIYSKVSPRDYLRGLARGVLIGSSICFLTRMTNININRPLELISGVISYILLRLDNHPSLYIMLREPSLRGEIFSIPQKVPAAYPTTMKEGN
RSILCYLQHVLRYEREAITASPENDWLWIFSDFRSSKMTYLTLITYQSHLLLQRVDKNLSKSMRANLRQMSSLMRQVLGGHGEDTLESDEDIQRLLKDSL
RRTRWVDQEVRHAARTMTGSYSPHRRVSRKAGCSEWVCSAQQVAVSTSANPAPASELDIRTLSRRLQNPLISGLRVVQWATGAHYKLKPILDDLNVFPSL
CLVVGDGSGGISRAVLNMFPDARLVFNSLLEVNDLMASGTHPLPPSAIMSGGDDIISRVIDFDSIWEKPSDLRNLTTWRYFQSVQEQVNMSYDLIICDAE
VTDIASINRITLLMSDFALSIDGPLYLVFKTYGTMLVNPDYRAIQHLSRAFPAVTGFITQMTSSFSSELYLRFSKRGKFFRDAEYLTSSTLREMSLVLFN
CSSPKSEMQRARSLNYQDLVRGFPDEVISNPYNEMIITLIDSDVESFLVHKMVDDLELQRGTLSKVSIIIAIMIVFSNRVFNVSKPLTDPLFYPPFDPKI
LRHFNICCSTMMYLSTALGDVPSFARLHDLYNRPITYYFRKQVIRGNIYLSWSWSDDTSVFKRVACNSSLSLSSHWIRLIYKIVKTTRLVGSIEDLSGEI
EKHLRGYNRWITLDDIRSRSSLLDYSCL
SLWLYGAHSESNRSRKCINDLAQFYYKSSPIEKLLNCTLGNRGLKTPPEGVLSCLARVDYDKAFGRYLANIYSSYLFFHVITLYMNALDWDEEKTILALW
RDITSIDTGKDLVKFKDQIWGLLIVTKDFVYSQSTGCLFDRNYTLMLKDLFLSRFNSLMILLSPPEPRYSDDLISQLCQLYIAGDQVLSMCGNSGYEVIK
ILEPYVVNSLVQRAEKFRPLIHSLGDFPTFIRDKVGQLEGTFGPSAKRFFKVLDQFDNIHDLVFVYGCYRHWGHPYIDYRKGLSKLYDQVHLKKVIDKSY
QECLASDLARRILRWGFDKYSKWYLDSRLLSRDHPLIPYIKTQTWPPRHIVDLVGDTWHKLPITQIFEIPESMDPSEILDDKSHSFTRTRLASWLSENRG
GPVPSEKVIITALSKPPVNPREFLKSIDLGGLPDEDLIIGLKPKERELKIEGRFFALMSWNLRLYFVITEKLLANYILPLFDALTMTDNLNKVFKKLIDR
VTGQGLLDYSRVTYAFRLDYEKWNNHQRLESTEDVFSVLDQVFGLKRVFSRTHEFFQRSWIYYSDRSDLIGLWEDQIYCLDMSDGPTCWNGQDGGLEGLR
QKGWSLVSLLMIDRESQTRNTRTKILAQGDNQVLCPTYMLSPGLSREGLLYELESISRNALSIYRAIEEGASKLGLIIKKEETMCSYDFLIYGKTPLFRG
NILVPESKRWARVSCISNDQIVNLANTMSTVSTNALTVAQHSQSLIKPMRDFLLMSVQAVFHYLLFSPILKGRVYKILSAEGDNFLLAMSRIIYLDPSLG
GVSGMSLGRFHIRQFSDPVSEGLSFWREIWLSSNESWIHALCQEAGNPDLGERTLESFTRLLEDPTTLNIKGGASPTILLKDAIRKALYDEVDEVENSEF
REAILLSKTHRDNFILFLKSIEPLFPRFLSELFSSSFLGIPESIIGLIQNSRTIRRQFRRSLSRTLEESFYNSETHGINRMTQTPQRVGRVWPCSSERAD
LLREISWGRKVVGTTVPHPSEMLGLIPKSSISCTCGAAGGGNPRISVSVLPSFDQSFFSRGPLKGYLGSSTSMSTQLFHAWEKVTNVHVVKRALSLKESI
NWFITRNSNRAQTLIRNIMSLTGPDFPLEEAPVFKRTGSALHRFKSARYSEGGYSSVCPNLLSHISVSTDTMSDLTQDGRNYDFMFQPLMLYAQTWTSEL
VQKDTRLKDSTFHWHLRCNKCIRPIDDMTLDTSQVFEFPDVSRRISRMVSGAVPHFRKLPDIRLRPGDFESLSGKEKSRHIGSAQGLLYSILVAIHDSGY
NDGTIFPVNIYSKVSPRDYLRGLARGVLIGSSICFLTRMTNININRPLELISGVISYILLRLDNHPSLYIMLREPSLRGEIFSIPQKVPAAYPTTMKEGN
RSILCYLQHVLRYEREAITASPENDWLWIFSDFRSSKMTYLTLITYQSHLLLQRVDKNLSKSMRANLRQMSSLMRQVLGGHGEDTLESDEDIQRLLKDSL
RRTRWVDQEVRHAARTMTGSYSPHRRVSRKAGCSEWVCSAQQVAVSTSANPAPASELDIRTLSRRLQNPLISGLRVVQWATGAHYKLKPILDDLNVFPSL
CLVVGDGSGGISRAVLNMFPDARLVFNSLLEVNDLMASGTHPLPPSAIMSGGDDIISRVIDFDSIWEKPSDLRNLTTWRYFQSVQEQVNMSYDLIICDAE
VTDIASINRITLLMSDFALSIDGPLYLVFKTYGTMLVNPDYRAIQHLSRAFPAVTGFITQMTSSFSSELYLRFSKRGKFFRDAEYLTSSTLREMSLVLFN
CSSPKSEMQRARSLNYQDLVRGFPDEVISNPYNEMIITLIDSDVESFLVHKMVDDLELQRGTLSKVSIIIAIMIVFSNRVFNVSKPLTDPLFYPPFDPKI
LRHFNICCSTMMYLSTALGDVPSFARLHDLYNRPITYYFRKQVIRGNIYLSWSWSDDTSVFKRVACNSSLSLSSHWIRLIYKIVKTTRLVGSIEDLSGEI
EKHLRGYNRWITLDDIRSRSSLLDYSCL
2128
Not Available
Not Available
11-10-2004
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
♦RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both acticities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
♦ RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.
2.7.7.48 , 2.1.1.56 , 2.7.7.88 , 2.1.1.296
Virion . Host cytoplasm . Note=L and P are packaged asymmetrically towards the blunt end of the virus. .
♦DOMAIN 612 800 RdRp catalytic.
♦ DOMAIN 1675 1872 Mononegavirus-type SAM-dependent 2'-O-MTase.
♦ DOMAIN 1675 1872 Mononegavirus-type SAM-dependent 2'-O-MTase.
Not Available
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available