Reviewed
Homo Sapiens (Human) [TaxID: 9606]
BPLF1
Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)
Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)
Various pathway(s) in which protein is involved
Not Available
Not Available
MSNGDWGQSQRPRGTGPMRGIRTMDVNAPGGGSGGSALRILGTASCNQAHCKFGRFAGIQCVSNCVLYLVKSFLAGRPLTSRPELDEVLDEGARLDALMR
QSGILKGHEMAQLTDVPSSVVLRGGGRVHIYRSAEIFGLVLFPAQIANSAVVQSLAEVLHGSYNGVAQFILYICDIYAGGIIIETDGSFYLFDPHCQKDA
APGTPAHVRVSTYAHDILQYVGAPGAQYTCVHLYFLPEAFETEDPRIFMLEHYGVYDFYEANGSGFDLVGPELVSSDGEAAGTPDADSSPPVMLPFERRI
IPYNLRPLPSRSFTSDSFPAARYSPAKTNSPPPSPASAAPASAAPASAAPASAAPASAAQASVAPASVAPASAAPASAAPDSAAPASSPPLFIPIPGLGH
TPGVPAPSTPPRASGSAAPQTPKRKKGLGKDSPHKKPTSGRRLPLSSTTDTEDDQLPRPPVPPHRPPSAARLPPPVIPIPHQSPPASPTPRRAPVSTIAP
SVTPSPRLPLQIPIPLPQAAPSNPEIPLTTPSPSPTAAAAPTATTLSPPPTQQQPLQSAAPAPSPPPTQQQPPQSAAPAPSPLLPQQQPPPSAAPAPSPL
LPQQQPPPSAARAPSPLPPQQQPLPSATPAPPPAQQLPPSATTLEPEKNNPSAADRAGTEISPSPPFGQQPSFGDDASGGSGLVRYLSDLEEPFLSMSDS
EEAESDLASDIPTTEDEDMFEDEVFSNSLESGSSAPTSPITLDTARSQYYQTTFDIETPEMDFVPLESNIARIAGHTYQEQAIVYDPASNREVPEADALS
MIDYLLVTVVLEQGLIRSRDRSAVLNLLEFLKDWSGHLQVPTLDLEQLLTSELNIQNLANMLSENKGRAGEFHEHLAAKLEACLPSLATKDAVRVDAGAK
MLAEIPQLAESDDGKFDLEAARRRLTDLLSGGDQEGEEGGGEPEDHSIYRGPHVDVPLVLDDESWKRLLSLAEAARTAVARQQAGVDEEDVRFLALLTAI
EYGAPPAASVPPFVHNVAVRSKNAALHVRRCTADIRDKVASAASDYLSYLEDPSLPTVMDFDDLLTHLRHTCQIIASLPLLNIRYTSIEWDYRELLYLGT
ALSDMSGIPWPLERVEEDDPSIAPLPEFETVAKKQKELETTRENEKRLRTILDDIEAMLGLAGVASAPGAPISPASPSATPANHDNPEATPPLADTAALT
IPVIEKYIANAGSIVGAAKNPTYIRLRDTIQQIVRSKKYLMNILKSITFYTIDNYIASFEESIDHLYRDLPVLDPEVQDGIDRILDPMVSEALHTFEMGN
RLTLEPARLVALQNFATHSTLKETAAAVNLLPGLLAVYDATVTGQAPEDALRLLSGLQNQLSQTLIPGKLKKRFLSYLQKLKNNNNDQLRQKEVQAWRLE
AEGFKPATEEQLEAFLDTAPNKELKRQYEKKLRQLMETGRKEKEKLREQEDKERRERRAREANEAWARIRKALGARPEPAPTSPDDWNTLLASLLPDNTD
SAAAAAAAVARNTDILDSLTQILAAMLLGITRVRRERLRSLLVDDGGAAERMEAAEPGWFTDIETGPLARLDAWPATPAATAKEGGGGRGAEEAAGALFR
ARTAADAIRSALAQTRQALQSPDMKSAVVNTDLEAPYAEYERGLAGLLEKRRAAEAALTAIVSEYVDRTLPEATNDPGQANLPPPPTIPQATAPPRLASD
LALWPKKPQLLTRRERDDLLQATGDFFSELLTEAEAAEVRALEEQVRESQTLMAKAHEMAASTRRGFHTALEAVLSRSRDEAPDDELRSLLPSPPKAPVQ
APLEAALARAAAGNGSWPYRKSLAAAKWIRGICEAVRGLSEGALALAGGAGAWLNLAAAADGEIHELTRLLEVEGMAQNSMDGMEELRLALATLDPKRVA
GGKETVADWKRRLSRLEAIIQEAQEESQLQGTLQDLVTQARGHTDPRQLKIVVEAARGLALGASAGSQYALLKDKLLRYASAKQSFLAFYETAQPTVFVK
HPLTNNLPLLITISAPPTGWGNGAPTRRAQFLAAAGPAKYAGTLWLETESPCDPLNPAYVSADTQEPLNYIPVYHNFLEYVMPTVLENPEAFSLTPAGRP
QAIGPPQDDQERRRRTLASVASARLSAAAADSYWDTWPDVESNAGELLREYVSAPKALMEDLADNPIVAMTLLAHASLIASRNHPPYPAPATDREVILLE
QREIMALLVGTHPAYAAAFLGAPSFYAGLGLVSALARDGGLGDLLSDSVLTYRLVRSPASGRGGMPSTTRGSDDGEDARRLTRHRIAGPPTGFIFFQDAW
EEMDTRAALWPHPEFLGLVHNQSTARARACMLLLARRCFAPEALQQLWHSLRPLEGPVAFQDYLRDFVKQAYTRGEELPRAEGLEVPRETPSSYGTVTGR
ALRNLMPYGTPITGPKRGSGDTIPVSVFEAAVAAAFLGRPLTLFVSSQYLFNLKTLGQVRVVAPLLYCDGHSEPFRSLVETISLNFLQDLDGYSESFEPE
MSIFARQAVWLRELLTEARAAKPKEARPPTVAILANRKNIIWKCFTYRHNLPDVQFYFNAAGASRWPTDVLNPSFYEHEDPPLPVGYQLPPNPRNVQELF
SGFPPRVGHGLVSGDGFQSADNTPASSDRLQQLGGGETDQGEEGSTTAESEASGPPSPQSPLLEKVAPGRPRDWLSPTSSPRDVTVTPGLAAPITLPGPR
LMARPYFGAETRASESPDRSPGTSPRPWPKDSLELLPQPAPQQPPSSPWASEQGPIVYTLSPHSTPSTASGSQKKHTIQIPGLVPSQKPSYPPSAPYKPG
QSTGGIAPTPSAASLTTFGLQPQDTQASSQDPPYGHSIMQREKKQQGGREEAAEIRPSATRLPTAVGLRPRAPVVAAGAAASATPAFDPGEAPSGLPIPQ
APALGSGLAAPAHTPVGALAPSPQKTQAQRPQDAAALPTPTIKAVGARPVPKATGALAAGARPRGQPTAAPPSAASPPRVSLPVRSRQQQSPAIPLPPMH
SGSEPGARPEVRLSQYRHAGPQTYTVQKEAPPSAASQLPKMPKCKDSMYYPPSGSARYPAPFQALSFSQSVASPAPSSDQTTLLWNTPSVVTQFLSIEDI
IREVVTGGSTSGDLVVPSGSPSSLSTAAPEQDLRYSLTLSQASRVLSRFVSQLRRKLERSTHRLIADLERLKFLYL
QSGILKGHEMAQLTDVPSSVVLRGGGRVHIYRSAEIFGLVLFPAQIANSAVVQSLAEVLHGSYNGVAQFILYICDIYAGGIIIETDGSFYLFDPHCQKDA
APGTPAHVRVSTYAHDILQYVGAPGAQYTCVHLYFLPEAFETEDPRIFMLEHYGVYDFYEANGSGFDLVGPELVSSDGEAAGTPDADSSPPVMLPFERRI
IPYNLRPLPSRSFTSDSFPAARYSPAKTNSPPPSPASAAPASAAPASAAPASAAPASAAQASVAPASVAPASAAPASAAPDSAAPASSPPLFIPIPGLGH
TPGVPAPSTPPRASGSAAPQTPKRKKGLGKDSPHKKPTSGRRLPLSSTTDTEDDQLPRPPVPPHRPPSAARLPPPVIPIPHQSPPASPTPRRAPVSTIAP
SVTPSPRLPLQIPIPLPQAAPSNPEIPLTTPSPSPTAAAAPTATTLSPPPTQQQPLQSAAPAPSPPPTQQQPPQSAAPAPSPLLPQQQPPPSAAPAPSPL
LPQQQPPPSAARAPSPLPPQQQPLPSATPAPPPAQQLPPSATTLEPEKNNPSAADRAGTEISPSPPFGQQPSFGDDASGGSGLVRYLSDLEEPFLSMSDS
EEAESDLASDIPTTEDEDMFEDEVFSNSLESGSSAPTSPITLDTARSQYYQTTFDIETPEMDFVPLESNIARIAGHTYQEQAIVYDPASNREVPEADALS
MIDYLLVTVVLEQGLIRSRDRSAVLNLLEFLKDWSGHLQVPTLDLEQLLTSELNIQNLANMLSENKGRAGEFHEHLAAKLEACLPSLATKDAVRVDAGAK
MLAEIPQLAESDDGKFDLEAARRRLTDLLSGGDQEGEEGGGEPEDHSIYRGPHVDVPLVLDDESWKRLLSLAEAARTAVARQQAGVDEEDVRFLALLTAI
EYGAPPAASVPPFVHNVAVRSKNAALHVRRCTADIRDKVASAASDYLSYLEDPSLPTVMDFDDLLTHLRHTCQIIASLPLLNIRYTSIEWDYRELLYLGT
ALSDMSGIPWPLERVEEDDPSIAPLPEFETVAKKQKELETTRENEKRLRTILDDIEAMLGLAGVASAPGAPISPASPSATPANHDNPEATPPLADTAALT
IPVIEKYIANAGSIVGAAKNPTYIRLRDTIQQIVRSKKYLMNILKSITFYTIDNYIASFEESIDHLYRDLPVLDPEVQDGIDRILDPMVSEALHTFEMGN
RLTLEPARLVALQNFATHSTLKETAAAVNLLPGLLAVYDATVTGQAPEDALRLLSGLQNQLSQTLIPGKLKKRFLSYLQKLKNNNNDQLRQKEVQAWRLE
AEGFKPATEEQLEAFLDTAPNKELKRQYEKKLRQLMETGRKEKEKLREQEDKERRERRAREANEAWARIRKALGARPEPAPTSPDDWNTLLASLLPDNTD
SAAAAAAAVARNTDILDSLTQILAAMLLGITRVRRERLRSLLVDDGGAAERMEAAEPGWFTDIETGPLARLDAWPATPAATAKEGGGGRGAEEAAGALFR
ARTAADAIRSALAQTRQALQSPDMKSAVVNTDLEAPYAEYERGLAGLLEKRRAAEAALTAIVSEYVDRTLPEATNDPGQANLPPPPTIPQATAPPRLASD
LALWPKKPQLLTRRERDDLLQATGDFFSELLTEAEAAEVRALEEQVRESQTLMAKAHEMAASTRRGFHTALEAVLSRSRDEAPDDELRSLLPSPPKAPVQ
APLEAALARAAAGNGSWPYRKSLAAAKWIRGICEAVRGLSEGALALAGGAGAWLNLAAAADGEIHELTRLLEVEGMAQNSMDGMEELRLALATLDPKRVA
GGKETVADWKRRLSRLEAIIQEAQEESQLQGTLQDLVTQARGHTDPRQLKIVVEAARGLALGASAGSQYALLKDKLLRYASAKQSFLAFYETAQPTVFVK
HPLTNNLPLLITISAPPTGWGNGAPTRRAQFLAAAGPAKYAGTLWLETESPCDPLNPAYVSADTQEPLNYIPVYHNFLEYVMPTVLENPEAFSLTPAGRP
QAIGPPQDDQERRRRTLASVASARLSAAAADSYWDTWPDVESNAGELLREYVSAPKALMEDLADNPIVAMTLLAHASLIASRNHPPYPAPATDREVILLE
QREIMALLVGTHPAYAAAFLGAPSFYAGLGLVSALARDGGLGDLLSDSVLTYRLVRSPASGRGGMPSTTRGSDDGEDARRLTRHRIAGPPTGFIFFQDAW
EEMDTRAALWPHPEFLGLVHNQSTARARACMLLLARRCFAPEALQQLWHSLRPLEGPVAFQDYLRDFVKQAYTRGEELPRAEGLEVPRETPSSYGTVTGR
ALRNLMPYGTPITGPKRGSGDTIPVSVFEAAVAAAFLGRPLTLFVSSQYLFNLKTLGQVRVVAPLLYCDGHSEPFRSLVETISLNFLQDLDGYSESFEPE
MSIFARQAVWLRELLTEARAAKPKEARPPTVAILANRKNIIWKCFTYRHNLPDVQFYFNAAGASRWPTDVLNPSFYEHEDPPLPVGYQLPPNPRNVQELF
SGFPPRVGHGLVSGDGFQSADNTPASSDRLQQLGGGETDQGEEGSTTAESEASGPPSPQSPLLEKVAPGRPRDWLSPTSSPRDVTVTPGLAAPITLPGPR
LMARPYFGAETRASESPDRSPGTSPRPWPKDSLELLPQPAPQQPPSSPWASEQGPIVYTLSPHSTPSTASGSQKKHTIQIPGLVPSQKPSYPPSAPYKPG
QSTGGIAPTPSAASLTTFGLQPQDTQASSQDPPYGHSIMQREKKQQGGREEAAEIRPSATRLPTAVGLRPRAPVVAAGAAASATPAFDPGEAPSGLPIPQ
APALGSGLAAPAHTPVGALAPSPQKTQAQRPQDAAALPTPTIKAVGARPVPKATGALAAGARPRGQPTAAPPSAASPPRVSLPVRSRQQQSPAIPLPPMH
SGSEPGARPEVRLSQYRHAGPQTYTVQKEAPPSAASQLPKMPKCKDSMYYPPSGSARYPAPFQALSFSQSVASPAPSSDQTTLLWNTPSVVTQFLSIEDI
IREVVTGGSTSGDLVVPSGSPSSLSTAAPEQDLRYSLTLSQASRVLSRFVSQLRRKLERSTHRLIADLERLKFLYL
3176
Not Available
Not Available
08-11-2005
Inferred from homology
| Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
|---|---|---|---|---|---|
| Alanine (A) | Leucine (L) | ||||
| Arginine (R) | Lysine (K) | ||||
| Asparagine (N) | Methionine (M) | ||||
| Aspartic Acid (D) | Phenylalanine (F) | ||||
| Cysteine (C) | Proline (P) | ||||
| Glutamine (Q) | Serine (S) | ||||
| Glutamic Acid (E) | Threonine (T) | ||||
| Glycine (G) | Tryptophan (W) | ||||
| Histidine (H) | Tyrosine (Y) | ||||
| Isoleucine (I) | Valine (V) |
| % Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
|---|---|---|
Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.
3.4.19.12 , 3.4.22.-
Virion tegument . Host cytoplasm . Host nucleus . Note=Tightly associated with the capsid. .
DOMAIN 41 258 Peptidase C76.
Not Available
Predicted/Modelled
Not Available
♦ACT_SITE 61 61
♦ ACT_SITE 193 193
♦ ACT_SITE 195 195
♦ ACT_SITE 193 193
♦ ACT_SITE 195 195
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available