Results | viHumans

UniProt ID

Q1HVG1

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

BZLF1[Gene ID: 5176210 ]

Protein Name

Trans-activator protein BZLF1 (EB1) (Zebra)

Organism Name

Epstein-Barr Virus (strain AG876) (HHV-4) (Human Herpesvirus 4)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Gammaherpesvirinae> Lymphocryptovirus> Epstein-Barr Virus (strain GD1) (HHV-4) (Human Herpesvirus 4)> Epstein-Barr Virus (strain AG876) (HHV-4) (Human Herpesvirus 4)

RefSeq

NC_007605.1 ; AJ507799.2

PubMed ID

16490228

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:5176210

Reactome

Not Available

Sequence

							MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSAAPTGSWFPAPQPAPENAYQAYAAPQLFPVSDI
TQNQQTNQAGGEAPQPGDNSTVQPAAAVVFACPGANQGQQLADIGAPQPAPAAAPARRTRKPLQPESLEECDSELDIKRYKNRVASRKCRAKFKHLLQHY
REVASAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLNF
						

Length

245

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

13-06-2006

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1) (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0003700 ; GO:0006351 ; GO:0039646 ; GO:0042025

Subcellular Location

Host nucleus .

Domain(s)

DOMAIN 178 228 bZIP.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available