Results | viHumans

UniProt ID

P48313

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

PTP[Gene ID: 2715933 ]

Protein Name

♦Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate terminal protein (iTP)
♦ Terminal protein (TP)]

Organism Name

Human Adenovirus F Serotype 40 (HAdV-40) (Human Adenovirus 40)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Adenoviridae> Mastadenovirus> Human Mastadenovirus F> Human Adenovirus F Serotype 40 (HAdV-40) (Human Adenovirus 40)

RefSeq

NC_001454.1 ; L19443.1

PubMed ID

8263936

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MALSVQDCARLTGQSVPAMERFSPLRNIWNRVREYARAATTAAGITWLSRYVYHYHRLMLEDLAPGTPATLRWPLYREPPPHFLVGYQYLVRTCNDYVFE
SRAYSRLRYTEITQPGMQVVNWSVMANCTYTINTGSYHRFVDLDDFQNTLTQIQQAVLAERVVADLALLQPLRGFGSTRMADRGELEIPVESLMQDYYKD
LRRCQNEAWGMADRLRIQQAGPKDVTLLATIRRLKTAYFNFLISSITSSAASLRIPHATVLSLPCDCDWLEAFLEKFSDPVQLDSLNEAWQSLPMQQMIR
CTVSALSLPQGPHLLPPLSGSGMQGGVFELRPRENGRAVTETMRRRRGEMIQRFIDRLPVRRRRRRQPVPAPVSPEGPAVEEEEFMEIEETPAAFEQEVR
ETVAEAIRLLQEELTFAARNSQFFNFAVDFYEAMDRLEALGDINEMTLRRWVMYFFVCEHIATTLNYLFQRLRNYAVFARHVELNIAQVVMRARNTVGDV
VYSRVWNENGLNAFSQLMRRISNDLAATVERAGHGELQDEEIDQFMSEIAYQDNSGDVQEILRQAAVNDADIDSVELSFRFRVRGPVVFSQRRHIQDLNR
RVVAYASQLRAQHQPLPELHADVPLPPLQANPHPPLPPDARPQRTM
						

Length

646

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-1996

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Protein covalently bound to the viral DNA that acts as a primer for viral genomic replication by DNA strand displacement. Assembles on the viral origin of replication in an initiation complex with viral polymerase, DBP, host NFIA and host POU2F1/OCT1. During initiation, the polymerase covalently couples the first dCTP with Ser-580 of pTP. The terminal protein stimulates the template activity over 20 fold compared to protein-free templates. Neo-synthesized viral genomes are linked to two preterminal proteins, one for each 5' end. These new genomes are encapsidated in the nucleus, and during capsid maturation by viral protease, preterminal protein is first cleaved into intermediary (iTP), then into mature TP. May play a role in host nuclear matrix localization of genomic DNA.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0006260 ; GO:0039693 ; GO:0044204

Subcellular Location

Host nucleus matrix .

Domain(s)

Not Available

Motif(s)

MOTIF 357 366 Nuclear localization signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available