Results | viHumans

UniProt ID

P36800

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

E6[Gene ID: 1489472 ]

Protein Name

Protein E6

Organism Name

Human Papillomavirus Type 7

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Papillomaviridae> Alphapapillomavirus> Alphapapillomavirus 8> Human Papillomavirus Type 7

RefSeq

NC_001595.1 ; X74463.1

PubMed ID

8205838

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1489472

Reactome

Not Available

Sequence

							MSARCGSTARTLFELCDQCNITLPTLQINCIFCNSILQTAEVLAFAFRELYVVWRNDFPFAACVKCLEFYGKVNQYRNFRYAAYAPTVEEETGLTILEVR
IRCCKCHKPLSPVEKTNHIVKKTQFFKLQDSWTGYCLHCWKKCMEKGQRSETSC
						

Length

154

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-1994

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation. In turn, apoptosis induced by DNA damage is inhibited. E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0006351 ; GO:0006355 ; GO:0030430 ; GO:0039503 ;
GO:0039526 ; GO:0042025 ; GO:0046872

Subcellular Location

Host cytoplasm . Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available