Reviewed
Homo Sapiens (Human) [TaxID: 9606]
E1[Gene ID: 1489429 ]
Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
Human Papillomavirus Type 34
Viruses> DsDNA Viruses> No RNA Stage> Papillomaviridae> Alphapapillomavirus> Alphapapillomavirus 11> Human Papillomavirus Type 34
Various pathway(s) in which protein is involved
Not Available
MADSGNWEGRCSGWFNVEAIVERKTGDAIPADENYDGDDTEDSEMGDFIDNAHISNIYSQQEIAQALYHSQQVNADNEAIRVLKRKFAGSAGSSPDSKRH
ELKHKQRSPHILTIRDTNTTSTHLLCEEQDSGYGNTEVETYERQVPGPGGCLQSTSSSNNGSQMASPGETNSGSSSISNMDIDMESTPITDITNILKSSN
VKATLLAKFKEVYGLSYMELVRPYKSDKTQCQDWVCAVFGVAPSLAESLKSLLTQYCLYIHLQCLTCSWGIIVLLLARFKCNKNRLTVQKLLHGLLNVTQ
EYMLIEPPRLRSTPCALYWYRTSLSNISETVGEVPEWIKRQTVVQHSLEDCQFDLSQMVQWAFDNDITNDCEIAYKYALLASEDSNAAAFLKSNAQAKYV
KDCGTMCRHYKAAERKQMTMSQWITHRCDLIDDGGNWKHIVQFLRYQQVEFVPFLIALKQFLKGIPKQNCIVIYGPPDTGKSHFGMSLMQFMQGVVISYV
NSNSHFWLSPLADAKMALLDDATPACWTYIDRYLRNALDGNPMCLDRKHKHLLQIKCPPLLITSNTNPKADDTWKYLHSRMKVFTFSNPFPFDSNGNPLY
QLTNENWKAFFTKTWSKLDLTEDDDKENDGDTVQTFKCVSGRNPRTV
ELKHKQRSPHILTIRDTNTTSTHLLCEEQDSGYGNTEVETYERQVPGPGGCLQSTSSSNNGSQMASPGETNSGSSSISNMDIDMESTPITDITNILKSSN
VKATLLAKFKEVYGLSYMELVRPYKSDKTQCQDWVCAVFGVAPSLAESLKSLLTQYCLYIHLQCLTCSWGIIVLLLARFKCNKNRLTVQKLLHGLLNVTQ
EYMLIEPPRLRSTPCALYWYRTSLSNISETVGEVPEWIKRQTVVQHSLEDCQFDLSQMVQWAFDNDITNDCEIAYKYALLASEDSNAAAFLKSNAQAKYV
KDCGTMCRHYKAAERKQMTMSQWITHRCDLIDDGGNWKHIVQFLRYQQVEFVPFLIALKQFLKGIPKQNCIVIYGPPDTGKSHFGMSLMQFMQGVVISYV
NSNSHFWLSPLADAKMALLDDATPACWTYIDRYLRNALDGNPMCLDRKHKHLLQIKCPPLLITSNTNPKADDTWKYLHSRMKVFTFSNPFPFDSNGNPLY
QLTNENWKAFFTKTWSKLDLTEDDDKENDGDTVQTFKCVSGRNPRTV
647
Not Available
Not Available
01-06-1994
Inferred from homology
Amino Acid | Count | % Frequency | Amino Acid | Count | % Frequency |
---|---|---|---|---|---|
Alanine (A) | Leucine (L) | ||||
Arginine (R) | Lysine (K) | ||||
Asparagine (N) | Methionine (M) | ||||
Aspartic Acid (D) | Phenylalanine (F) | ||||
Cysteine (C) | Proline (P) | ||||
Glutamine (Q) | Serine (S) | ||||
Glutamic Acid (E) | Threonine (T) | ||||
Glycine (G) | Tryptophan (W) | ||||
Histidine (H) | Tyrosine (Y) | ||||
Isoleucine (I) | Valine (V) |
% Number of Residues in Helices | % Number of Residues in Strands | % Number of Residues in Coils |
---|---|---|
ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity. Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer. Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori. Subsequently, two hexamers will be created. The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
3.6.4.12
Host nucleus .
DOMAIN 449 599 SF3 helicase.
MOTIF 84 86 Nuclear localization signal.
Predicted/Modelled
Not Available
Not Available
Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.
Not Available
- Million Molecules
Best 20 Hit molecules
Not Available