Results | viHumans

UniProt ID

P35259

Status

Reviewed

Host

Chlorocebus Aethiops (Green Monkey) (Cercopithecus Aethiops) [TaxID: 9534]; Homo Sapiens (Human) [TaxID: 9606]; Rousettus Aegyptiacus (Egyptian Rousette) (Egyptian Fruit Bat) [TaxID: 9407]

Gene Name

VP35[Gene ID: 920948 ]

Protein Name

Polymerase cofactor VP35

Organism Name

Lake Victoria Marburgvirus (strain Musoke-80) (MARV) (Marburg Virus (strain Kenya/Musoke/1980))

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Filoviridae> Marburgvirus> Marburg Marburgvirus> Lake Victoria Marburgvirus (strain Musoke-80) (MARV) (Marburg Virus (strain Kenya/Musoke/1980))

RefSeq

NC_001608.3 ; DQ217792.1

PubMed ID

1626422 ; 16379005 ; 16282487 ; 17958906

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:920948

Reactome

Not Available

Sequence

							MWDSSYMQQVSEGLMTGKVPIDQVFGANPLEKLYKRRKPKGTVGLQCSPCLMSKATSTDDIIWDQLIVKRTLADLLIPINRQISDIQSTLSEVTTRVHEI
ERQLHEITPVLKMGRTLEAISKGMSEMLAKYDHLVISTGRTTAPAAAFDAYLNEHGVPPPQPAIFKDLGVAQQACSKGTMVKNATTDAADKMSKVLELSE
ETFSKPNLSAKDLALLLFTHLPGNNTPFHILAQVLSKIAYKSGKSGAFLDAFHQILSEGENAQAALTRLSRTFDAFLGVVPPVIRVKNFQTVPRPSQKSL
RAVPPNPTIDKGWVCVYSSEQGETRALKI
						

Length

329

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-02-1994

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex.

EC

Not Available

Experimentally known GO terms

GO:0006351 ; GO:0019013 ; GO:0030430

Subcellular Location

Virion. Host cytoplasm .

Domain(s)

DOMAIN 204 329 VP35 IID.

Motif(s)

Not Available

Methods of 3D structure generation

X-ray crystallography (4)

Experimetally known structure

4GH9 4GHA 5TOH 5TOI

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available