Results | viHumans

UniProt ID

P33804

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

B3R B4R C11R D2L D4R[Gene ID: 1486396 ]

Protein Name

Pro-variola growth factor (Pro-VGF) [Cleaved into: Variola growth factor (VGF) (Secreted epidermal growth factor-like)]

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8384129 ; 8264798 ; 8661439 ; 10639322

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486396

Reactome

Not Available

Sequence

							MSMKYLMLLFAAMIIRSFANSGNAIETTLSEITNTTTDIPAIRLCGPEGDRYCFHGICIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSY
IPSPGIVLVLLVSIIVCCLLFVYRFTRRTNKLPLQDMVVP
						

Length

140

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

15-06-2010

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Variola growth factor stimulates cellular proliferation (hyperplasia) around infected cells. This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells. Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival. The activation by host EFGR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo (By similarity).

EC

Not Available

Experimentally known GO terms

GO:0005154 ; GO:0005576 ; GO:0007176 ; GO:0008083 ; GO:0016021 ;
GO:0016032 ; GO:0033644

Subcellular Location

♦ Pro-variola growth factor: Host membrane .
♦ Variola growth factor: Secreted.

Domain(s)

DOMAIN 41 81 EGF-like.

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available