Results | viHumans

UniProt ID

P33059

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

H3L I3L[Gene ID: 1486441 ]

Protein Name

Envelope protein H3 (Ag35) (Virion envelope protein p35)

Organism Name

Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Poxviridae> Chordopoxvirinae> Orthopoxvirus> Variola Virus> Variola Virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox Virus)

RefSeq

NC_001611.1 ; X69198.1

PubMed ID

8383392 ; 8384129

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

vg:1486441

Reactome

Not Available

Sequence

							MATVNKTPVIVVPVIDRPPSETFPNLHEHINDQKFDDVKDNEVMPEKRNVVIVKDDPDHYKDYAFIHWTGGNIRNDDKYTHFFSGFCNTMCTEETKRNIA
RHLALWDSKFFTELENKKVEYVVIVENDNVIEDITFLRPVLKAMHDKKIDILQMREIITGNKVKTELVMDKNHVIFTYTGGYDVSLSAYIIRVTTALNIV
DEIIKSGGLSSGFYFEIARIENEIKINRQIMDNSAKYVEHDPRLVAEHRFENMKPNFWSRIGTAAVKRYPGVMYAFTTPLISFFGLFDINVIGLIVILFI
MFMLIFNVKSKLLWFLTGTFVTAFI
						

Length

325

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1993

Protein Existence

Evidence at transcript level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Envelope protein that binds to heparan sulfate on the cell surface and might provide virion attachment to target cell.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019031 ; GO:0019062 ; GO:0046718 ; GO:0055036

Subcellular Location

♦ Virion membrane
♦ Single-pass membrane protein . Note=Component of the mature virion (MV) membrane. Becomes membrane associated presumably during virus maturation. The mature virion is located in the cytoplasm of infected cells and is probably released by cell lysis (By similarity). .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available