Results | viHumans

UniProt ID

P27234

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

L2

Protein Name

Minor capsid protein L2

Organism Name

Human Papillomavirus Type 35

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Papillomaviridae> Alphapapillomavirus> Alphapapillomavirus 9> Human Papillomavirus Type 35

RefSeq

Not Available

PubMed ID

8205838 ; 1310198

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MRHKRSTKRVKRASATQLYRTCKAAGTCPPDVIPKVEGNTVADQILKYGSMAVFFGGLGIGSGSGTGGRSGYVPLGTTPPTAATNIPIRPPVTVESIPLD
TIGPLDSSIVSLVEETSFIESGAPVVTPRVPPTTGFTITTSTDTTPAILDVTSISTHDNPTFTDPSVLHPPTPAETSGHFVLSSSSISTHNYEEIPMDTF
IVSTDSNNITNSTPIPGSRPTTRLGLYSKGTQQVKVVDPAFMTSPAKLITYDNPAYEGLNPDTTLQFEHEDISLAPDPDFMDIIALHRPALTSRKGTIRY
SRVGNKRTMHTRSGKAIGARVHYYQDLSSITEDIELQPLQHVPSSLPHTTVSTSLNDGMFDIYAPIDTEEDIIFSASSNNTLYTTSNTAYVPSNTTIPLS
SGYDIPITAGPDIVFNSNTITNTVLPVPTGPIYSIIADGGDFYLHPSYYLLKRRRKRIPYFFADVSVAV
						

Length

469

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-06-1994

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0005198 ; GO:0019028 ; GO:0042025 ; GO:0046718 ;
GO:0075521 ; GO:0075732

Subcellular Location

Virion . Host nucleus .

Domain(s)

Not Available

Motif(s)

MOTIF 1 13 Nuclear localization signal. ; MOTIF 450 458 Nuclear localization signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available