Results | viHumans

UniProt ID

P27024

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

G

Protein Name

Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

Organism Name

Human Respiratory Syncytial Virus A (strain Rsb6190)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Mononegavirales> Pneumoviridae> Orthopneumovirus> Human Respiratory Syncytial Virus> Human Respiratory Syncytial Virus A> Human Respiratory Syncytial Virus A (strain Rsb6190)

RefSeq

Not Available

PubMed ID

1895054

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MSKTKDQRTAKTLEKTWDTLNHLLFISSCLYKLNLKSIAQITLSILAMIISTSLIIAAIIFIASANNKVTLTTAIIQDATSQIKNTTPTYLTQNPQLGIS
FFNLSGTTSQTTAILALTTPSVESILQSTTVKTKNTTTTQIQPSKPTTKQRQNKPPNKPNNDFHFEVFNFVPCSICSNNPTCWAICKRIPSKKPGKKTTT
KPTKKPTIKTTKKDHKPQTTKPKEAPSTKPTEKPTINITKPNIRTTLLTNSTTGNLEHTSQEETLHSTSSEGNTSPSQVYTTSEYLSQPTSPSNITNQ
						

Length

298

Alternate Sequence

VAR_SEQ 1 47 Missing (in isoform Secreted glycoprotein G)

Non-standard residue

Not Available

Date of last Sequence modification

01-08-1992

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

♦Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (By similarity).
♦ Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.

EC

Not Available

Experimentally known GO terms

GO:0005576 ; GO:0016021 ; GO:0019062 ; GO:0030683 ; GO:0044228 ;
GO:0046718 ; GO:0055036

Subcellular Location

♦ Virion membrane. Host cell surface .
♦ Isoform Secreted glycoprotein G: Secreted.

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available