Results | viHumans

UniProt ID

P14349

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

Gag

Protein Name

♦Gag polyprotein (Pr71Gag) [Cleaved into: Gag protein (p68Gag)
♦ p3 (p3Gag)]

Organism Name

Human Spumaretrovirus (SFVcpz(hu)) (Human Foamy Virus)

Taxonomic Lineage

Viruses> Retro-transcribing Viruses> Retroviridae> Spumaretrovirinae> Spumavirus> Simian Foamy Virus> Human Spumaretrovirus (SFVcpz(hu)) (Human Foamy Virus)

RefSeq

Not Available

PubMed ID

2451755 ; 8970944 ; 8995637 ; 10438890 ; 15308736 ; 15858022 ; 16160174 ; 12857789 ; 12908768 ;
15358259

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MASGSNVEEYELDVEALVVILRDRNIPRNPLHGEVIGLRLTEGWWGQIERFQMVRLILQDDDNEPLQRPRYEVIQRAVNPHTMFMISGPLAELQLAFQDL
DLPEGPLRFGPLANGHYVQGDPYSSSYRPVTMAETAQMTRDELEDVLNTQSEIEIQMINLLELYEVETRALRRQLAERSSTGQGGISPGAPRSRPPVSSF
SGLPSLPSIPGIHPRAPSPPRATSTPGNIPWSLGDDSPPSSSFPGPSQPRVSFHPGNPFVEEEGHRPRSQSRERRREILPAPVPSAPPMIQYIPVPPPPP
IGTVIPIQHIRSVTGEPPRNPREIPIWLGRNAPAIDGVFPVTTPDLRCRIINAILGGNIGLSLTPGDCLTWDSAVATLFIRTHGTFPMHQLGNVIKGIVD
QEGVATAYTLGMMLSGQNYQLVSGIIRGYLPGQAVVTALQQRLDQEIDNQTRAETFIQHLNAVYEILGLNARGQSIRASVTPQPRPSRGRGRGQNTSRPS
QGPANSGRGRQRPASGQSNRGSSTQNQNQDNLNQGGYNLRPRTYQPQRYGGGRGRRWNDNTNNQESRPSDQGSQTPRPNQAGSGVRGNQSQTPRPAAGRG
GRGNHNRNQRSSGAGDSRAVNTVTQSATSSTDESSSAVTAASGGDQRD
						

Length

648

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

11-07-2006

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome.

EC

Not Available

Experimentally known GO terms

GO:0003677 ; GO:0003723 ; GO:0019013 ; GO:0019076 ; GO:0030430 ;
GO:0039702 ; GO:0042025 ; GO:0044163 ; GO:0046718 ; GO:0075521

Subcellular Location

♦ Gag protein: Virion. Host nucleus. Host cytoplasm. Note=Nuclear at initial phase, cytoplasmic at assembly. Shortly after infection, Gag protein is targeted to centrosomes. It is then actively transported into the nucleus thanks to its nuclear localization signal. In the late phases of infection, Gag proteins assemble in the cytoplasm to form the virion's capsids.
♦ p3: Virion.

Domain(s)

Not Available

Motif(s)

MOTIF 284 287 PTAP/PSAP motif.; MOTIF 535 556 Nuclear localization signal.

Methods of 3D structure generation

X-ray crystallography (3); NMR spectroscopy (2)

Experimetally known structure

4JMR 4JNH 5M1G 5M1H 5MLU

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available