Results | viHumans

UniProt ID

P12592

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

NS

Protein Name

Non-structural protein 1 (NS1) (NS1A)

Organism Name

Influenza B Virus (strain B/GA/1986)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Orthomyxoviridae> Betainfluenzavirus> Influenza B Virus> Influenza B Virus (strain B/GA/1986)

RefSeq

NC_002205.1 ;  AF102017.1 ;  NC_002206.1 ;  AF102017.1 ;  NC_002207.1 ;  M14880.1 ;  NC_002208.1 ;
K01395.1 ;  NC_002209.1 ;  J02095.1 ;  NC_002210.1 ;  AF101982.1 ;  NC_002211.1 ;  K00423.1 ;
RNA 1:NC_002204.1 ;  M14880.1

PubMed ID

3267218 ; 12758165

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MADNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPESKRMSLEERKAIGIKMMKVLLFMNPSAGVEGF
EPDCMKNPSNSNCPNCNWADYPPTPGKYLDDIEEVPENVDDPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDIRNVLSLRVLVNGTFLKHPNGD
KSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERFNEGHSKPIRAAETAVGVLSQFGQEHRLSPEEGDN
						

Length

281

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-10-1989

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins. Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA.

EC

Not Available

Experimentally known GO terms

GO:0003723 ; GO:0030430 ; GO:0039502 ; GO:0039579 ; GO:0039580 ;
GO:0042025

Subcellular Location

Host cytoplasm . Host nucleus .

Domain(s)

Not Available

Motif(s)

MOTIF 50 55 Nuclear localization signal.

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available