Results | viHumans

UniProt ID

P09309

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

61

Protein Name

E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61) (RING-type E3 ubiquitin transferase IE61)

Organism Name

Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Varicellovirus> Human Herpesvirus 3 (HHV-3) (Varicella-zoster Virus)> Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

RefSeq

NC_001348.1 ; X04370.1

PubMed ID

3018124 ; 1366099 ; 20392849 ; 22090112 ; 26085158

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MDTILAGGSGTSDASDNTCTICMSTVSDLGKTMPCLHDFCFVCIRAWTSTSVQCPLCRCPVQSILHKIVSDTSYKEYEVHPSDDDGFSEPSFEDSIDILP
GDVIDLLPPSPGPSRESIQQPTSRSSREPIQSPNPGPLQSSAREPTAESPSDSQQDSIQPPTRDSSPGVTKTCSTASFLRKVFFKDQPAVRSATPVVYGS
IESAQQPRTGGQDYRDRPVSVGINQDPRTMDRLPFRATDRGTEGNARFPCYMQPLLGWLDDQLAELYQPEIVEPTKMLILNYIGIYGRDEAGLKTSLRCL
LHDSTGPFVTNMLFLLDRCTDPTRLTMQTWTWKDTAIQLITGPIVRPETTSTGETSRGDERDTRLVNTPQKVRLFSVLPGIKPGSARGAKRRLFHTGRDV
KRCLTIDLTSESDSACKGSKTRKVASPQGESNTPSTSGSTSGSLKHLTKKSSAGKAGKGIPNKMKKS
						

Length

467

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Evidence at protein level

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

RING-finger E3 ubiquitin ligase that degrades host SP100, one of the major components of ND10 nuclear bodies, thereby disrupting the organization of these bodies. Plays also a role in the inhibition of host NF-kappa-B pathway by blocking the SCF(BTRC)-mediated addition of ubiquitin chains to host I-kappa-B-alpha/NFKBIA, thereby interfering with its degradation.

EC

2.3.2.27

Experimentally known GO terms

GO:0003677 ; GO:0006351 ; GO:0006355 ; GO:0016740 ; GO:0039648 ;
GO:0046872

Subcellular Location

Not Available

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available