Results | viHumans

UniProt ID

P09307

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

ORF59

Protein Name

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

Organism Name

Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Varicellovirus> Human Herpesvirus 3 (HHV-3) (Varicella-zoster Virus)> Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

RefSeq

NC_001348.1 ; X04370.1

PubMed ID

3018124

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MDVSGEPTVCSNAYANEMKLSDSKDIYVLAHPVTKKTRKRPRGLPLGVKLDPPTFKLNNMSHHYDTETFTPVSSQLDSVEVFSKFNISPEWYDLLSDELK
EPYAKGIFLEYNRLLNSGEEILPSTGDIFAWTRFCGPQSIRVVIIGQDPYPTAGHAHGLAFSVKRGITPPSSLKNIFAALMESYPNMTPPTHGCLESWAR
QGVLLLNTTLTVRRGTPGSHVYLGWGRLVQRVLQRLCENRTGLVFMLWGAHAQKTTQPNSRCHLVLTHAHPSPLSRVPFRNCRHFVQANEYFTRKGEPEI
DWSVI
						

Length

305

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.

EC

3.2.2.27

Experimentally known GO terms

GO:0004844 ; GO:0006284 ; GO:0042025

Subcellular Location

Host nucleus .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

ACT_SITE 148 148 Proton acceptor.

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available