Results | viHumans

UniProt ID

P09248

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

RIR1 ORF19

Protein Name

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

Organism Name

Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

Taxonomic Lineage

Viruses> DsDNA Viruses> No RNA Stage> Herpesvirales> Herpesviridae> Alphaherpesvirinae> Varicellovirus> Human Herpesvirus 3 (HHV-3) (Varicella-zoster Virus)> Varicella-zoster Virus (strain Dumas) (HHV-3) (Human Herpesvirus 3)

RefSeq

NC_001348.1 ; X04370.1

PubMed ID

3018124 ; 18990579

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MEFKRIFNTVHDIINRLCQHGYKEYIIPPESTTPVELMEYISTIVSKLKAVTRQDERVYRCCGELIHCRINLRSVSMETWLTSPILCLTPRVRQAIEGRR
DEIRRAILEPFLKDQYPALATLGLQSALKYEDFYLTKLEEGKLESLCQFFLRLAATVTTEIVNLPKIATLIPGINDGYTWTDVCRVFFTALACQKIVPAT
PVMMFLGRETGATASCYLMDPESITVGRAVRAITGDVGTVLQSRGGVGISLQSLNLIPTENQTKGLLAVLKLLDCMVMAINSDCERPTGVCVYIEPWHVD
LQTVLATRGMLVRDEIFRCDNIFCCLWTPDLFFERYLSYLKGASNVQWTLFDNRADILRTLHGEAFTSTYLRLEREGLGVSSVPIQDIAFTIIRSAAVTG
SPFLMFKDACNRNYHMNTQGNAITGSNLCTEIVQKADAHQHGVCNLASINLTTCLSKGPVSFNLNDLQLTARTTVIFLNGVLAAGNFPCKKSCKGVKNNR
SLGIGIQGLHTTCLRLGFDLTSQPARRLNVQIAELMLYETMKTSMEMCKIGGLAPFKGFTESKYAKGWLHQDGFSTISYLDLPWCTLRDDICAYGLYNSQ
FLALMPTVSSAQVTECSEGFSPIYNNMFSKVTTSGELLRPNLDLMDELRDMYSCEEKRLEVINILEKNQWSVIRSFGCLSNSHPLLKYKTAFEYEQEDLV
DMCAERAPFIDQSQSMTLFIEERPDGTIPASKIMNLLIRAYKAGLKTGMYYCKIRKATNSGLFAGGELTCTSCAL
						

Length

775

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

01-07-1989

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

EC

1.17.4.1

Experimentally known GO terms

GO:0004748 ; GO:0005524 ; GO:0006260 ; GO:0019046

Subcellular Location

Not Available

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

♦ACT_SITE 427 427 Proton acceptor.
♦ ACT_SITE 429 429 Cysteine radical intermediate.
♦ ACT_SITE 431 431 Proton acceptor.

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available