Results | viHumans

UniProt ID

P03463

Status

Reviewed

Host

Homo Sapiens (Human) [TaxID: 9606]

Gene Name

HA

Protein Name

♦Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain
♦ Hemagglutinin HA2 chain]

Organism Name

Influenza B Virus (strain B/Singapore/222/1979)

Taxonomic Lineage

Viruses> SsRNA Viruses> SsRNA Negative-strand Viruses> Orthomyxoviridae> Betainfluenzavirus> Influenza B Virus> Influenza B Virus (strain B/Singapore/222/1979)

RefSeq

NC_002205.1 ;  AF102017.1 ;  NC_002206.1 ;  AF102017.1 ;  NC_002207.1 ;  M14880.1 ;  NC_002208.1 ;
K01395.1 ;  NC_002209.1 ;  J02095.1 ;  NC_002210.1 ;  AF101982.1 ;  NC_002211.1 ;  K00423.1 ;
RNA 1:NC_002204.1 ;  M14880.1

PubMed ID

6348701

Pathways Involved

Various pathway(s) in which protein is involved

KEGG

Not Available

Reactome

Not Available

Sequence

							MKAIIVLLMVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPNCLNCTDLDVALGRPKCMGTIPSAKASILH
EVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTRNVINAERAPGGPYIIGTSGSCPNVTNGNGFFATMAWAVPKDNKTATNPLTVEVPYICTKGEDQ
ITVWGFHSDTETQMVKLYGDSKPQKFTSSANGVTTHYVSQIGGFPNQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSL
PLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKERGFFGAIAGFLEGGWEGMIAGWHGYTSHGAHGVAVAADLKS
TQEAINKITKNLNSLSELEVKNLQRLSGAMDELHNEILELDEKVDDLRADTISSQIELAVLLSNEGIINSEDEHLLALERKLKKMLGPSAVDIGNGCFET
KHKCNQTCLDRIAAGTFNAGEFSLPTFDSLNITAASLNDDGLDNHTILLYYSTAASSLAVTLMIAIFIVYMVSRDNVSCSICL
						

Length

583

Alternate Sequence

Not Available

Non-standard residue

Not Available

Date of last Sequence modification

21-07-1986

Protein Existence

Inferred from homology

Amino Acid composition

Amino Acid	Count	% Frequency	Amino Acid	Count	% Frequency
Alanine (A)			Leucine (L)
Arginine (R)			Lysine (K)
Asparagine (N)			Methionine (M)
Aspartic Acid (D)			Phenylalanine (F)
Cysteine (C)			Proline (P)
Glutamine (Q)			Serine (S)
Glutamic Acid (E)			Threonine (T)
Glycine (G)			Tryptophan (W)
Histidine (H)			Tyrosine (Y)
Isoleucine (I)			Valine (V)

Sum of Absolute Deviation from Amino Acid Occurrence Frequencies

Aliphatic Index

Instability Index

Secondary Structure features

% Number of Residues in Helices	% Number of Residues in Strands	% Number of Residues in Coils

Structural Difficulty(SD) index

Role(s)

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

EC

Not Available

Experimentally known GO terms

GO:0016021 ; GO:0019031 ; GO:0019062 ; GO:0019064 ; GO:0020002 ;
GO:0039654 ; GO:0046789 ; GO:0055036 ; GO:0075509

Subcellular Location

♦ Virion membrane
♦ Single-pass type I membrane protein . Host apical cell membrane
♦ Single-pass type I membrane protein . Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts. .

Domain(s)

Not Available

Motif(s)

Not Available

Methods of 3D structure generation

Predicted/Modelled

Experimetally known structure

Not Available

Active Site(s)

Not Available

Predicted 3D Structures

Protein couldn't be modeled using I-Tasser and Raptor X because of length constraints of the software.

Experimentally known Ligand(s)

Not Available

Virtually Screened Ligands

Virtual screening has been performed using RASPD

						Million Molecules

					
Best 20 Hit molecules 
Not Available